Digital breast tomosynthesis as an adjunct to digital mammography for detecting and characterising invasive lobular cancers: a multi-reader study

G. Mariscotti; Manuela Durando; N. Houssami; C. Zuiani; Laura Martincich; Viviana Londero; E. Caramia; Paola Clauser; P. Campanino; E. Regini; A. Luparia; Isabella Castellano; Laura Bergamasco; Anna Sapino; Paolo Fonio; M. Bazzocchi; G. Gandini

Digital breast tomosynthesis as an adjunct to digital mammography for detecting and characterising invasive lobular cancers: a multi-reader study

G. Mariscotti, Manuela Durando, N. Houssami, C. Zuiani, Laura Martincich, Viviana Londero, E. Caramia, Paola Clauser, P. Campanino, E. Regini, A. Luparia, Isabella Castellano, Laura Bergamasco, Anna Sapino, Paolo Fonio, M. Bazzocchi, G. Gandini

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To examine the interpretive performance of digital breast tomosynthesis (DBT) as an
adjunct to digital mammography (DM) compared to DM alone in a series of invasive lobular
carcinomas (ILCs) and to assess whether DBT can be used to characterise ILC.
MATERIALS AND METHODS: A retrospective, multi-reader study was conducted of 83
mammographic examinations of women with 107 newly diagnosed ILCs ascertained at histology.
Consenting women underwent both DM and DBT acquisitions. Twelve radiologists, with
varying mammography experience, interpreted DM images alone, reporting lesion location,
mammographic features, and malignancy probability using the Breast Imaging-Reporting and
Data System (BI-RADS) categories 1e5; they then reviewed DBT images in addition to DM, and
reported the same parameters. Statistical analyses compared sensitivity, false-positive rates
(FPR), and interpretive performance using the receiver operating characteristics (ROC) curve
and the area under the curve (AUC), for reading with DM versus DM plus DBT.

Original language	English
Journal	Clinical Radiology
Publication status	Published - 2016

Cite this

Mariscotti, G., Durando, M., Houssami, N., Zuiani, C., Martincich, L., Londero, V., Caramia, E., Clauser, P., Campanino, P., Regini, E., Luparia, A., Castellano, I., Bergamasco, L., Sapino, A., Fonio, P., Bazzocchi, M., & Gandini, G. (2016). Digital breast tomosynthesis as an adjunct to digital mammography for detecting and characterising invasive lobular cancers: a multi-reader study. Clinical Radiology.

Mariscotti, G, Durando, M, Houssami, N, Zuiani, C, Martincich, L, Londero, V, Caramia, E, Clauser, P, Campanino, P, Regini, E, Luparia, A, Castellano, I, Bergamasco, L, Sapino, A, Fonio, P, Bazzocchi, M & Gandini, G 2016, 'Digital breast tomosynthesis as an adjunct to digital mammography for detecting and characterising invasive lobular cancers: a multi-reader study', Clinical Radiology.

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title = "Digital breast tomosynthesis as an adjunct to digital mammography for detecting and characterising invasive lobular cancers: a multi-reader study",

abstract = "AIM: To examine the interpretive performance of digital breast tomosynthesis (DBT) as anadjunct to digital mammography (DM) compared to DM alone in a series of invasive lobularcarcinomas (ILCs) and to assess whether DBT can be used to characterise ILC.MATERIALS AND METHODS: A retrospective, multi-reader study was conducted of 83mammographic examinations of women with 107 newly diagnosed ILCs ascertained at histology.Consenting women underwent both DM and DBT acquisitions. Twelve radiologists, withvarying mammography experience, interpreted DM images alone, reporting lesion location,mammographic features, and malignancy probability using the Breast Imaging-Reporting andData System (BI-RADS) categories 1e5; they then reviewed DBT images in addition to DM, andreported the same parameters. Statistical analyses compared sensitivity, false-positive rates(FPR), and interpretive performance using the receiver operating characteristics (ROC) curveand the area under the curve (AUC), for reading with DM versus DM plus DBT.",

author = "G. Mariscotti and Manuela Durando and N. Houssami and C. Zuiani and Laura Martincich and Viviana Londero and E. Caramia and Paola Clauser and P. Campanino and E. Regini and A. Luparia and Isabella Castellano and Laura Bergamasco and Anna Sapino and Paolo Fonio and M. Bazzocchi and G. Gandini",

note = "A. Sapino {\`e} affiliata anche con l'Istituto di Candiolo, come da convenzione.",

year = "2016",

language = "English",

journal = "Clinical Radiology",

issn = "0009-9260",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Digital breast tomosynthesis as an adjunct to digital mammography for detecting and characterising invasive lobular cancers: a multi-reader study

AU - Mariscotti, G.

AU - Durando, Manuela

AU - Houssami, N.

AU - Zuiani, C.

AU - Martincich, Laura

AU - Londero, Viviana

AU - Caramia, E.

AU - Clauser, Paola

AU - Campanino, P.

AU - Regini, E.

AU - Luparia, A.

AU - Castellano, Isabella

AU - Bergamasco, Laura

AU - Sapino, Anna

AU - Fonio, Paolo

AU - Bazzocchi, M.

AU - Gandini, G.

N1 - A. Sapino è affiliata anche con l'Istituto di Candiolo, come da convenzione.

PY - 2016

Y1 - 2016

N2 - AIM: To examine the interpretive performance of digital breast tomosynthesis (DBT) as anadjunct to digital mammography (DM) compared to DM alone in a series of invasive lobularcarcinomas (ILCs) and to assess whether DBT can be used to characterise ILC.MATERIALS AND METHODS: A retrospective, multi-reader study was conducted of 83mammographic examinations of women with 107 newly diagnosed ILCs ascertained at histology.Consenting women underwent both DM and DBT acquisitions. Twelve radiologists, withvarying mammography experience, interpreted DM images alone, reporting lesion location,mammographic features, and malignancy probability using the Breast Imaging-Reporting andData System (BI-RADS) categories 1e5; they then reviewed DBT images in addition to DM, andreported the same parameters. Statistical analyses compared sensitivity, false-positive rates(FPR), and interpretive performance using the receiver operating characteristics (ROC) curveand the area under the curve (AUC), for reading with DM versus DM plus DBT.

AB - AIM: To examine the interpretive performance of digital breast tomosynthesis (DBT) as anadjunct to digital mammography (DM) compared to DM alone in a series of invasive lobularcarcinomas (ILCs) and to assess whether DBT can be used to characterise ILC.MATERIALS AND METHODS: A retrospective, multi-reader study was conducted of 83mammographic examinations of women with 107 newly diagnosed ILCs ascertained at histology.Consenting women underwent both DM and DBT acquisitions. Twelve radiologists, withvarying mammography experience, interpreted DM images alone, reporting lesion location,mammographic features, and malignancy probability using the Breast Imaging-Reporting andData System (BI-RADS) categories 1e5; they then reviewed DBT images in addition to DM, andreported the same parameters. Statistical analyses compared sensitivity, false-positive rates(FPR), and interpretive performance using the receiver operating characteristics (ROC) curveand the area under the curve (AUC), for reading with DM versus DM plus DBT.

M3 - Article

C2 - 27210245

SN - 0009-9260

JO - Clinical Radiology

JF - Clinical Radiology

ER -

Digital breast tomosynthesis as an adjunct to digital mammography for detecting and characterising invasive lobular cancers: a multi-reader study

Abstract

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