TY - JOUR
T1 - Diffusion-weighted magnetic resonance imaging in patients selected for radical cystectomy
T2 - Detection rate of pelvic lymph node metastases
AU - Papalia, Rocco
AU - Simone, Giuseppe
AU - Grasso, Rosario
AU - Augelli, Raffaele
AU - Faiella, Eliodoro
AU - Guaglianone, Salvatore
AU - Cazzato, Roberto
AU - Vescovo, Riccardo Del
AU - Ferriero, Mariaconsiglia
AU - Zobel, Bruno
AU - Gallucci, Michele
PY - 2012/4
Y1 - 2012/4
N2 - Objective • To evaluate whether DW-MRI improves the detection of pelvic lymph nodes metastates in patients with bladder cancer undergoing radical cystectomy. Patients and Methods • 36 patients with CT scan negative for nodal metastates underwent DW-MRI before surgery. Diagnostic accuracy of DW-MRI was compared with histopathological findings. Results • Mean ADC value was 0.85 × 10 -3 mm 3/s in the nodal metastatic group and 1 × 10 -3 mm 3/s in the nodal non-metastatic group (P = 0.02). • The ADC cut-off value, obtained by the ROC curve was 0.86 × 10 -3 mm 3/s. • Patient-based sensitivity, specificity and positive and negative predictive values were 76.4%, 89.4%, 26.6%, and 71.4%, respectively. Conclusions • DW-MRI may be used to differentiate metastatic from non-metastatic lymph nodes in patients with high-grade bladder cancer.
AB - Objective • To evaluate whether DW-MRI improves the detection of pelvic lymph nodes metastates in patients with bladder cancer undergoing radical cystectomy. Patients and Methods • 36 patients with CT scan negative for nodal metastates underwent DW-MRI before surgery. Diagnostic accuracy of DW-MRI was compared with histopathological findings. Results • Mean ADC value was 0.85 × 10 -3 mm 3/s in the nodal metastatic group and 1 × 10 -3 mm 3/s in the nodal non-metastatic group (P = 0.02). • The ADC cut-off value, obtained by the ROC curve was 0.86 × 10 -3 mm 3/s. • Patient-based sensitivity, specificity and positive and negative predictive values were 76.4%, 89.4%, 26.6%, and 71.4%, respectively. Conclusions • DW-MRI may be used to differentiate metastatic from non-metastatic lymph nodes in patients with high-grade bladder cancer.
KW - bladder cancer
KW - diffusion weighted MRI
KW - extended pelvic lymphadenectomy
KW - lymph node metastasis
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U2 - 10.1111/j.1464-410X.2011.10446.x
DO - 10.1111/j.1464-410X.2011.10446.x
M3 - Article
C2 - 21883835
AN - SCOPUS:84858439898
SN - 1464-4096
VL - 109
SP - 1031
EP - 1036
JO - BJU International
JF - BJU International
IS - 7
ER -