TY - JOUR
T1 - Differential in situ expression of IL-17 in skin diseases
AU - Fischer-Stabauer, Mattias
AU - Boehner, Alexander
AU - Eyerich, Stefanie
AU - Carbone, Teresa
AU - Traidl-Hoffmann, Claudia
AU - Schmidt-Weber, Carsten B.
AU - Cavani, Andrea
AU - Ring, Johannes
AU - Hein, Ruediger
AU - Eyerich, Kilian
PY - 2012/12
Y1 - 2012/12
N2 - Background: Interleukin (IL)-17 is a key molecule for epithelial immunity and inflammation. Objectives: To quantify IL-17 expression in situ in a large panel of cutaneous diseases. Materials&Methods: 289 samples of the 30 most common cutaneous infectious, autoimmune, inflammatory and tumor diseases were stained for IL-17 immunohistochemically. Results: IL-17 expression strongly varied between the diseases, but was conserved within each disease. The major cellular sources of IL-17 were T cells and granulocytes. Skin diseases caused by extracellular microbials were infiltrated by many IL-17+ cells, while intracellular infections were scarcely positive for IL-17. While autoimmune diseases were mostly accompanied by IL-17+ T cells, IL-17+ granulocytes were dominant in neutrophilic dermatoses. Conclusion: Cutaneous diseases show a characteristic pattern of IL-17+ cellular infiltrate. These patterns are relevant for the clinician, since therapeutic approaches targeting differentiation of Th17 cells as well as direct targeting of IL-17 are or will become available.
AB - Background: Interleukin (IL)-17 is a key molecule for epithelial immunity and inflammation. Objectives: To quantify IL-17 expression in situ in a large panel of cutaneous diseases. Materials&Methods: 289 samples of the 30 most common cutaneous infectious, autoimmune, inflammatory and tumor diseases were stained for IL-17 immunohistochemically. Results: IL-17 expression strongly varied between the diseases, but was conserved within each disease. The major cellular sources of IL-17 were T cells and granulocytes. Skin diseases caused by extracellular microbials were infiltrated by many IL-17+ cells, while intracellular infections were scarcely positive for IL-17. While autoimmune diseases were mostly accompanied by IL-17+ T cells, IL-17+ granulocytes were dominant in neutrophilic dermatoses. Conclusion: Cutaneous diseases show a characteristic pattern of IL-17+ cellular infiltrate. These patterns are relevant for the clinician, since therapeutic approaches targeting differentiation of Th17 cells as well as direct targeting of IL-17 are or will become available.
KW - Interleukin (IL)-17
KW - Neutrophil granulocyte
KW - T cell
KW - Th17
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U2 - 10.1684/ejd.2012.1854
DO - 10.1684/ejd.2012.1854
M3 - Article
C2 - 23211678
AN - SCOPUS:84877075690
SN - 1167-1122
VL - 22
SP - 781
EP - 784
JO - European Journal of Dermatology
JF - European Journal of Dermatology
IS - 6
ER -