Differential effect of repeated treatment with l-DOPA on dopamine-D1 or -D2 receptors

M. Parenti; C. Flauto; E. Parati; A. Vescovi; A. Groppetti

doi:10.1016/0028-3908(86)90261-3

Differential effect of repeated treatment with l-DOPA on dopamine-D1 or -D2 receptors

M. Parenti, C. Flauto, E. Parati, A. Vescovi, A. Groppetti

Research output: Contribution to journal › Article › peer-review

Abstract

Unilateral degeneration of the nigro-striatal dopaminergic pathway with 6-hydroxydopamine induced controlateral rotations to apomorphine injection, increased [³H]spiroperidol binding and enhanced sensitivity of adenylate cyclase to dopamine stimulation in lesioned striata. Prolonged L-DOPA administration counteracted the increased density of [3H]-spiroperidol binding sites but further enhanced the hypersensitivity of adenylate cyclase to dopamine. Also apomorphine-induced controlateral rotations were potentiated. This effect was antagonized by SCH-23390. These results suggest that dopaminergic D1 and D2 receptors are differently affected by prolonged L-DOPA treatment. This study was supported by grants from Italian CNR and MPI.

Original language	English
Pages (from-to)	331-334
Number of pages	4
Journal	Neuropharmacology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0028-3908(86)90261-3
Publication status	Published - 1986

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Drug Discovery
Pharmacology

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title = "Differential effect of repeated treatment with l-DOPA on dopamine-D1 or -D2 receptors",

abstract = "Unilateral degeneration of the nigro-striatal dopaminergic pathway with 6-hydroxydopamine induced controlateral rotations to apomorphine injection, increased [3H]spiroperidol binding and enhanced sensitivity of adenylate cyclase to dopamine stimulation in lesioned striata. Prolonged L-DOPA administration counteracted the increased density of [3H]-spiroperidol binding sites but further enhanced the hypersensitivity of adenylate cyclase to dopamine. Also apomorphine-induced controlateral rotations were potentiated. This effect was antagonized by SCH-23390. These results suggest that dopaminergic D1 and D2 receptors are differently affected by prolonged L-DOPA treatment. This study was supported by grants from Italian CNR and MPI.",

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T1 - Differential effect of repeated treatment with l-DOPA on dopamine-D1 or -D2 receptors

AU - Parenti, M.

AU - Flauto, C.

AU - Parati, E.

AU - Vescovi, A.

AU - Groppetti, A.

PY - 1986

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N2 - Unilateral degeneration of the nigro-striatal dopaminergic pathway with 6-hydroxydopamine induced controlateral rotations to apomorphine injection, increased [3H]spiroperidol binding and enhanced sensitivity of adenylate cyclase to dopamine stimulation in lesioned striata. Prolonged L-DOPA administration counteracted the increased density of [3H]-spiroperidol binding sites but further enhanced the hypersensitivity of adenylate cyclase to dopamine. Also apomorphine-induced controlateral rotations were potentiated. This effect was antagonized by SCH-23390. These results suggest that dopaminergic D1 and D2 receptors are differently affected by prolonged L-DOPA treatment. This study was supported by grants from Italian CNR and MPI.

AB - Unilateral degeneration of the nigro-striatal dopaminergic pathway with 6-hydroxydopamine induced controlateral rotations to apomorphine injection, increased [3H]spiroperidol binding and enhanced sensitivity of adenylate cyclase to dopamine stimulation in lesioned striata. Prolonged L-DOPA administration counteracted the increased density of [3H]-spiroperidol binding sites but further enhanced the hypersensitivity of adenylate cyclase to dopamine. Also apomorphine-induced controlateral rotations were potentiated. This effect was antagonized by SCH-23390. These results suggest that dopaminergic D1 and D2 receptors are differently affected by prolonged L-DOPA treatment. This study was supported by grants from Italian CNR and MPI.

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Differential effect of repeated treatment with l-DOPA on dopamine-D1 or -D2 receptors

Abstract

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