Diagnostic features of thyroid nodules in pediatrics

Andrea Corrias, Alessandro Mussa, Federico Baronio, Teresa Arrigo, Mariacarolina Salerno, Maria Segni, Maria Cristina Vigone, Roberto Gastaldi, Giuseppa Zirilli, Gerdi Tuli, Luciano Beccaria, Lorenzo Iughetti, Silvia Einaudi, Giovanna Weber, Filippo De Luca, Alessandra Cassio

Research output: Contribution to journalArticlepeer-review


Objective: To investigate a cohort of pediatric patients with thyroid nodules, defining histotype frequency and differences between subjects with hyperthyroidism and euthyroidism and benign and malignant nodules. Design: Retrospective cohort. Setting: Consecutive cases from 9 Italian pediatric endocrinology centers for the last 10 years. Patients: One hundred twenty pediatric patients with thyroid nodules. Intervention: Doppler ultrasonography was performed in 71 subjects; scintiscan, in 56; fine-needle aspiration biopsy in 104; and 63 underwent surgery. Main Outcome Measures: The differences in clinical, laboratory, and ultrasonographic data between patients with hyperthyroidism and euthyroidism and malignant and benign nodules were evaluated. Results: One hundred fourteen patients had euthyroidism and 6, hyperthyroidism. The latter had more compressive signs (P=.003), greater nodule diameter (P=.02), intranodular vascularization pattern (P=.01), and increased scintiscan uptake (P

Original languageEnglish
Pages (from-to)714-719
Number of pages6
JournalArchives of Pediatrics and Adolescent Medicine
Issue number8
Publication statusPublished - Aug 2010

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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