TY - JOUR
T1 - Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients
T2 - Guidelines from the European Association for Neuro-Oncology
AU - Hoang-Xuan, Khê
AU - Bessell, Eric
AU - Bromberg, Jacoline
AU - Hottinger, Andreas F.
AU - Preusser, Matthias
AU - Rudà, Roberta
AU - Schlegel, Uwe
AU - Siegal, Tali
AU - Soussain, Carole
AU - Abacioglu, Ufuk
AU - Cassoux, Nathalie
AU - Deckert, Martina
AU - Dirven, Clemens M F
AU - Ferreri, Andrés J M
AU - Graus, Francesc
AU - Henriksson, Roger
AU - Herrlinger, Ulrich
AU - Taphoorn, Martin
AU - Soffietti, Riccardo
AU - Weller, Michael
PY - 2015/7/1
Y1 - 2015/7/1
N2 - The management of primary CNS lymphoma is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the very few controlled studies available. In 2013, the European Association of Neuro-Oncology created a multidisciplinary task force to establish evidence-based guidelines for immunocompetent adults with primary CNS lymphoma. In this Review, we present these guidelines, which provide consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary CNS lymphoma. Specifically, we address aspects of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with autologous stem-cell transplantation, radiotherapy, intraocular manifestations, and management of elderly patients. The guidelines should aid clinicians in their daily practice and decision making, and serve as a basis for future investigations in neuro-oncology.
AB - The management of primary CNS lymphoma is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the very few controlled studies available. In 2013, the European Association of Neuro-Oncology created a multidisciplinary task force to establish evidence-based guidelines for immunocompetent adults with primary CNS lymphoma. In this Review, we present these guidelines, which provide consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary CNS lymphoma. Specifically, we address aspects of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with autologous stem-cell transplantation, radiotherapy, intraocular manifestations, and management of elderly patients. The guidelines should aid clinicians in their daily practice and decision making, and serve as a basis for future investigations in neuro-oncology.
UR - http://www.scopus.com/inward/record.url?scp=84937440406&partnerID=8YFLogxK
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U2 - 10.1016/S1470-2045(15)00076-5
DO - 10.1016/S1470-2045(15)00076-5
M3 - Article
C2 - 26149884
AN - SCOPUS:84937440406
SN - 1470-2045
VL - 16
SP - e322-e332
JO - The Lancet Oncology
JF - The Lancet Oncology
IS - 7
ER -