Developmental differences of antinociceptive effects of oxotremorine in two inbred strains of mice

F. Pavone; D. Consorti; S. Fagioli

doi:10.1016/0165-3806(89)90071-0

Developmental differences of antinociceptive effects of oxotremorine in two inbred strains of mice

F. Pavone, D. Consorti, S. Fagioli

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

During development the C57BL/6 and DBA/2 mouse strains present morphological variations in cholinergic forebrain structures correlated with different behavioral reactivities to cholinergic agents. The present research assessed that these strain-dependent differences are also present in cholinergic-mediated analgesia. The administration of oxotremorine (0.0025, 0.005 and 0.01 mg/kg) to 30- and 60-day-old C57 and DBA mice resulted in dose- age- and strain-dependent analgesia. In particular oxotremorine is more effective in DBA/2 than in C57BL/6 mice and the latter strain showed a significant decrease of analgesic response in adulthood.

Original language	English
Pages (from-to)	156-160
Number of pages	5
Journal	Developmental Brain Research
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(89)90071-0
Publication status	Published - Sept 1 1989

Keywords

Analgesia
Mouse
Ontogeny
Oxotremorine

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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10.1016/0165-3806(89)90071-0

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abstract = "During development the C57BL/6 and DBA/2 mouse strains present morphological variations in cholinergic forebrain structures correlated with different behavioral reactivities to cholinergic agents. The present research assessed that these strain-dependent differences are also present in cholinergic-mediated analgesia. The administration of oxotremorine (0.0025, 0.005 and 0.01 mg/kg) to 30- and 60-day-old C57 and DBA mice resulted in dose- age- and strain-dependent analgesia. In particular oxotremorine is more effective in DBA/2 than in C57BL/6 mice and the latter strain showed a significant decrease of analgesic response in adulthood.",

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AU - Pavone, F.

AU - Consorti, D.

AU - Fagioli, S.

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AB - During development the C57BL/6 and DBA/2 mouse strains present morphological variations in cholinergic forebrain structures correlated with different behavioral reactivities to cholinergic agents. The present research assessed that these strain-dependent differences are also present in cholinergic-mediated analgesia. The administration of oxotremorine (0.0025, 0.005 and 0.01 mg/kg) to 30- and 60-day-old C57 and DBA mice resulted in dose- age- and strain-dependent analgesia. In particular oxotremorine is more effective in DBA/2 than in C57BL/6 mice and the latter strain showed a significant decrease of analgesic response in adulthood.

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Developmental differences of antinociceptive effects of oxotremorine in two inbred strains of mice

Abstract

Keywords

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