TY - JOUR
T1 - Development of Exhaustion and Acquisition of Regulatory Function by Infiltrating CD8+CD28- T Lymphocytes Dictate Clinical Outcome in Head and Neck Cancer
AU - Fenoglio, Daniela
AU - Belgioia, Liliana
AU - Parodi, Alessia
AU - Missale, Francesco
AU - Bacigalupo, Almalina
AU - Tarke, Alison
AU - Incandela, Fabiola
AU - Negrini, Simone
AU - Vecchio, Stefania
AU - Altosole, Tiziana
AU - Vlah, Sara
AU - Astone, Giuseppina
AU - Costabile, Francesca
AU - Ascoli, Alessandro
AU - Ferrera, Francesca
AU - Schenone, Guido
AU - De Palma, Raffaele
AU - Signori, Alessio
AU - Peretti, Giorgio
AU - Corvò, Renzo
AU - Filaci, Gilberto
PY - 2021/5/6
Y1 - 2021/5/6
N2 - Head and neck squamous cell carcinoma (HNSCC) has a poor clinical outcome despite the presence of a rich CD8+ T cell tumor infiltrate in the majority of patients. This may be due to alterations of tumor infiltrating CD8+ T cells. Here, we performed a characterization of HNSCC infiltrating CD8+ T cells in a cohort of 30 patients. The results showed that differential intratumoral frequency of CD8+CD28+ T cells, CD8+CD28- T cells, and CD8+CD28-CD127-CD39+ Treg distinguished between HNSCC patients who did or did not respond to treatment. Moreover, high PD1 expression identified a CD8+CD28- T cell subpopulation, phenotypically/functionally corresponding to CD8+CD28-CD127-CD39+ Treg, which showed a high expression of markers of exhaustion. This observation suggests that development of exhaustion and acquisition of regulatory properties may configure the late differentiation stage for intratumoral effector T cells, a phenomenon we define as effector-to-regulatory T cell transition.
AB - Head and neck squamous cell carcinoma (HNSCC) has a poor clinical outcome despite the presence of a rich CD8+ T cell tumor infiltrate in the majority of patients. This may be due to alterations of tumor infiltrating CD8+ T cells. Here, we performed a characterization of HNSCC infiltrating CD8+ T cells in a cohort of 30 patients. The results showed that differential intratumoral frequency of CD8+CD28+ T cells, CD8+CD28- T cells, and CD8+CD28-CD127-CD39+ Treg distinguished between HNSCC patients who did or did not respond to treatment. Moreover, high PD1 expression identified a CD8+CD28- T cell subpopulation, phenotypically/functionally corresponding to CD8+CD28-CD127-CD39+ Treg, which showed a high expression of markers of exhaustion. This observation suggests that development of exhaustion and acquisition of regulatory properties may configure the late differentiation stage for intratumoral effector T cells, a phenomenon we define as effector-to-regulatory T cell transition.
U2 - 10.3390/cancers13092234
DO - 10.3390/cancers13092234
M3 - Article
C2 - 34066538
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 9
ER -