Development of a simulation environment for Cerenkov luminescence imaging

Marco Pagliazzi, Esther Ciarrocchi, Alberto Del Guerra, Nicola Belcari, Federico Boschi, Antonello E. Spinelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In vivo Cerenkov luminescence imaging (CLI) is a demanding application requiring advanced pre-clinical small animal optical imaging devices. Here we propose a Monte Carlo based simulation workflow aimed to improve the development of an efficient Cerenkov optical imager for small animals. Our work makes use of a modular approach by considering open source, freely available or custom built software to solve the forward light propagation problem from source to detector in the following steps: i) simulation of the efficiency of Cerenkov light production of beta-emitting radionuclide in tissue using GEANT4 ii) optical transport of the simulated emitted photons through a precise mouse CT-segmented model using Molecular Optical Simulation Environment (MOSE), iii) free space transport of light from the mouse surface to a CCD sensor and simulation of the system response. Results showed the effects of the choice of lens and sensor based on system characteristics. An internal 90-Y source was simulated considering a mouse phantom and the Cerenkov light detection by a CCD. We conclude that the modular approach presented in this work combines the strengths of the different simulation codes used and thus provides a complete work frame for optical simulations.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposium Conference Record
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
Publication statusPublished - 2013
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013


Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
Country/TerritoryKorea, Republic of

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging
  • Radiation


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