Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis.: Journal of hepatology

Giammauro Berardi; Zenichi Morise; Carlo Sposito; Kazuharu Igarashi; Valentina Panetta; Ilaria Simonelli; Sungho Kim; Brian K. P. Goh; Shoji Kubo; Shogo Tanaka; Yutaka Takeda; Giuseppe Maria Ettorre; Gregory C. Wilson; Matteo Cimino; Chung-Yip Chan; Guido Torzilli; Tan To Cheung; Hironori Kaneko; Vincenzo Mazzaferro; David A. Geller; Ho-Seong Han; Akishige Kanazawa; Go Wakabayashi; Roberto Ivan Troisi

doi:10.1016/j.jhep.2019.08.032

Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis. Journal of hepatology

Giammauro Berardi, Zenichi Morise, Carlo Sposito, Kazuharu Igarashi, Valentina Panetta, Ilaria Simonelli, Sungho Kim, Brian K. P. Goh, Shoji Kubo, Shogo Tanaka, Yutaka Takeda, Giuseppe Maria Ettorre, Gregory C. Wilson, Matteo Cimino, Chung-Yip Chan, Guido Torzilli, Tan To Cheung, Hironori Kaneko, Vincenzo Mazzaferro, David A. GellerHo-Seong Han, Akishige Kanazawa, Go Wakabayashi, Roberto Ivan Troisi

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND & AIMS: Treatment allocation in patients with hepatocellular carcinoma (HCC) on a background of Child-Pugh B (CP-B) cirrhosis is controversial. Liver resection has been proposed in small series with acceptable outcomes, but data are limited. The aim of this study was to evaluate the outcomes of patients undergoing liver resection for HCC in CP-B cirrhosis, focusing on the surgical risks and survival. METHODS: Patients were retrospectively pooled from 14 international referral centers from 2002 to 2017. Postoperative and oncological outcomes were investigated. Prediction models for surgical risks, disease-free survival and overall survival were constructed. RESULTS: A total of 253 patients were included, of whom 57.3% of patients had a preoperative platelet count

Original language	English
Pages (from-to)	75-84
Number of pages	10
Journal	Journal of Hepatology
Volume	72
Issue number	1
DOIs	https://doi.org/10.1016/j.jhep.2019.08.032
Publication status	Published - 2020

Keywords

*Hepatocellular carcinoma
*Advanced liver cirrhosis
*Child-Pugh B
*Liver resection

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Berardi, G., Morise, Z., Sposito, C., Igarashi, K., Panetta, V., Simonelli, I., Kim, S., Goh, B. K. P., Kubo, S., Tanaka, S., Takeda, Y., Ettorre, G. M., Wilson, G. C., Cimino, M., Chan, C-Y., Torzilli, G., Cheung, T. T., Kaneko, H., Mazzaferro, V., ... Troisi, R. I. (2020). Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis. Journal of hepatology. Journal of Hepatology, 72(1), 75-84. https://doi.org/10.1016/j.jhep.2019.08.032

Berardi, G, Morise, Z, Sposito, C, Igarashi, K, Panetta, V, Simonelli, I, Kim, S, Goh, BKP, Kubo, S, Tanaka, S, Takeda, Y, Ettorre, GM, Wilson, GC, Cimino, M, Chan, C-Y, Torzilli, G, Cheung, TT, Kaneko, H, Mazzaferro, V, Geller, DA, Han, H-S, Kanazawa, A, Wakabayashi, G & Troisi, RI 2020, 'Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis. Journal of hepatology', Journal of Hepatology, vol. 72, no. 1, pp. 75-84. https://doi.org/10.1016/j.jhep.2019.08.032

@article{e46e861024f04b0ca34a40226f32871c,

title = "Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis.: Journal of hepatology",

abstract = "BACKGROUND & AIMS: Treatment allocation in patients with hepatocellular carcinoma (HCC) on a background of Child-Pugh B (CP-B) cirrhosis is controversial. Liver resection has been proposed in small series with acceptable outcomes, but data are limited. The aim of this study was to evaluate the outcomes of patients undergoing liver resection for HCC in CP-B cirrhosis, focusing on the surgical risks and survival. METHODS: Patients were retrospectively pooled from 14 international referral centers from 2002 to 2017. Postoperative and oncological outcomes were investigated. Prediction models for surgical risks, disease-free survival and overall survival were constructed. RESULTS: A total of 253 patients were included, of whom 57.3% of patients had a preoperative platelet count ",

keywords = "*Hepatocellular carcinoma, *Advanced liver cirrhosis, *Child-Pugh B, *Liver resection",

author = "Giammauro Berardi and Zenichi Morise and Carlo Sposito and Kazuharu Igarashi and Valentina Panetta and Ilaria Simonelli and Sungho Kim and Goh, {Brian K. P.} and Shoji Kubo and Shogo Tanaka and Yutaka Takeda and Ettorre, {Giuseppe Maria} and Wilson, {Gregory C.} and Matteo Cimino and Chung-Yip Chan and Guido Torzilli and Cheung, {Tan To} and Hironori Kaneko and Vincenzo Mazzaferro and Geller, {David A.} and Ho-Seong Han and Akishige Kanazawa and Go Wakabayashi and Troisi, {Roberto Ivan}",

year = "2020",

doi = "10.1016/j.jhep.2019.08.032",

language = "English",

volume = "72",

pages = "75--84",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis.

T2 - Journal of hepatology

AU - Berardi, Giammauro

AU - Morise, Zenichi

AU - Sposito, Carlo

AU - Igarashi, Kazuharu

AU - Panetta, Valentina

AU - Simonelli, Ilaria

AU - Kim, Sungho

AU - Goh, Brian K. P.

AU - Kubo, Shoji

AU - Tanaka, Shogo

AU - Takeda, Yutaka

AU - Ettorre, Giuseppe Maria

AU - Wilson, Gregory C.

AU - Cimino, Matteo

AU - Chan, Chung-Yip

AU - Torzilli, Guido

AU - Cheung, Tan To

AU - Kaneko, Hironori

AU - Mazzaferro, Vincenzo

AU - Geller, David A.

AU - Han, Ho-Seong

AU - Kanazawa, Akishige

AU - Wakabayashi, Go

AU - Troisi, Roberto Ivan

PY - 2020

Y1 - 2020

N2 - BACKGROUND & AIMS: Treatment allocation in patients with hepatocellular carcinoma (HCC) on a background of Child-Pugh B (CP-B) cirrhosis is controversial. Liver resection has been proposed in small series with acceptable outcomes, but data are limited. The aim of this study was to evaluate the outcomes of patients undergoing liver resection for HCC in CP-B cirrhosis, focusing on the surgical risks and survival. METHODS: Patients were retrospectively pooled from 14 international referral centers from 2002 to 2017. Postoperative and oncological outcomes were investigated. Prediction models for surgical risks, disease-free survival and overall survival were constructed. RESULTS: A total of 253 patients were included, of whom 57.3% of patients had a preoperative platelet count

AB - BACKGROUND & AIMS: Treatment allocation in patients with hepatocellular carcinoma (HCC) on a background of Child-Pugh B (CP-B) cirrhosis is controversial. Liver resection has been proposed in small series with acceptable outcomes, but data are limited. The aim of this study was to evaluate the outcomes of patients undergoing liver resection for HCC in CP-B cirrhosis, focusing on the surgical risks and survival. METHODS: Patients were retrospectively pooled from 14 international referral centers from 2002 to 2017. Postoperative and oncological outcomes were investigated. Prediction models for surgical risks, disease-free survival and overall survival were constructed. RESULTS: A total of 253 patients were included, of whom 57.3% of patients had a preoperative platelet count

KW - Hepatocellular carcinoma

KW - Advanced liver cirrhosis

KW - Child-Pugh B

KW - Liver resection

U2 - 10.1016/j.jhep.2019.08.032

DO - 10.1016/j.jhep.2019.08.032

M3 - Article

SN - 0168-8278

VL - 72

SP - 75

EP - 84

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 1

ER -

Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis. Journal of hepatology

Abstract

Keywords

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