Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer

Nicoletta Caronni, Elisa Montaldo, Luca Mezzanzanica, Francesco Cilenti, Marco Genua, Renato Ostuni

Research output: Contribution to journalReview articlepeer-review


Most, if not all, aspects of carcinogenesis are influenced by the tumor microenvironment (TME), a complex architecture of cells, matrix components, soluble signals, and their dynamic interactions in the context of physical traits of the tissue. Expanding application of technologies for high-dimensional analyses with single-cell resolution has begun to decipher the contributions of the immune system to cancer progression and its implications for therapy. In this review, we will discuss the multifaceted roles of tumor-associated macrophages and neutrophils, focusing on factors that subvert tissue immune homeostasis and offer therapeutic opportunities for TME reprogramming. By performing a critical analysis of available datasets, we elaborate on diversification mechanisms and unifying principles of myeloid cell heterogeneity in human tumors.

Original languageEnglish
Pages (from-to)220-236
Number of pages17
JournalImmunological Reviews
Issue number1
Publication statusPublished - Mar 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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