Detection of predictive markers for therapeutic stratification of salivary glands tumors

Monica Cantile, Simona Losito, Francesco Longo, Gabriella Aquino, Gabriella Malzone, Franco Fulciniti, Francesco Caponigro, Renato Franco, Franco Ionna, Gerardo Botti

Research output: Contribution to journalArticlepeer-review


Malignant tumors of salivary glands are rare lesions, often with poor prognosis. At present, surgery represents the only therapeutic choice, whereas chemotherapy is employed as palliative treatment in advanced disease. Over the years several molecular alterations associated with the pathogenesis and progression of the salivary glands tumors have been well-characterized. Particularly, the mutational status and/or aberrant expression of certain markers, such as EGFR, HER2, cKIT, BRAF and AR, also identified in some tumor histotypes of the salivary glands, currently represent molecular targets for new and efficacious drugs routinely employed in the treatment of other neoplasias, such as breast, lungs, GIST and melanoma. The expression analysis of these biomarkers associated with histomorphological data, could then provide the oncologist the opportunity to create a proper stratification of patients for customized therapies. This review represents an overview of the lesions of the salivary glands best characterized in terms of molecular aspects, focusing the attention on those markers and molecular alterations which can be important in the diagnosis as well as in the therapeutic stratification of these tumors.

Original languageEnglish
Pages (from-to)785-796
Number of pages12
JournalCurrent Drug Targets
Issue number8
Publication statusPublished - 2014


  • Malignant salivary glands tumors
  • Predictive markers
  • Therapeutic stratification

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine
  • Medicine(all)


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