TY - JOUR
T1 - Detection of micrometastatic cells in breast cancer by RT-PCR for the mammaglobin gene
AU - Bossolasco, Patrizia
AU - Ricci, Clara
AU - Farina, Gabriella
AU - Soligo, Davide
AU - Pedretti, Donata
AU - Scanni, Alberto
AU - Deliliers, Giorgio Lambertenghi
PY - 2002
Y1 - 2002
N2 - The detection of circulating cancer cells in the bone marrow (BM) and peripheral blood (PB) of patients with solid tumors may be useful for disease staging. To this aim, we evaluated the expression of the mammaglobin gene by reverse transcriptase polymerase chain reaction (RT-PCR) in 60 patients with breast cancer. Moreover, several controls were examined to test the specificity of this marker. The positive cases included 23.6% of the patients with and 9% of those without metastasis. Only 4/60 negative controls analyzed were positive by PCR. Our results show high specificity and a good correlation with disease status.
AB - The detection of circulating cancer cells in the bone marrow (BM) and peripheral blood (PB) of patients with solid tumors may be useful for disease staging. To this aim, we evaluated the expression of the mammaglobin gene by reverse transcriptase polymerase chain reaction (RT-PCR) in 60 patients with breast cancer. Moreover, several controls were examined to test the specificity of this marker. The positive cases included 23.6% of the patients with and 9% of those without metastasis. Only 4/60 negative controls analyzed were positive by PCR. Our results show high specificity and a good correlation with disease status.
KW - Breast neoplasm
KW - Mammaglobin
KW - Neoplasm circulating cells
KW - RT-PCR
UR - http://www.scopus.com/inward/record.url?scp=0036952136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036952136&partnerID=8YFLogxK
U2 - 10.1016/S0361-090X(02)00009-0
DO - 10.1016/S0361-090X(02)00009-0
M3 - Article
C2 - 12088204
AN - SCOPUS:0036952136
SN - 0361-090X
VL - 26
SP - 60
EP - 63
JO - Cancer Detection and Prevention
JF - Cancer Detection and Prevention
IS - 1
ER -