Detection of high levels of Survivin-immunoglobulin M immune complex in sera from hepatitis C virus infected patients with cirrhosis

Claudia Matteucci; Roberta Sorrentino; Lia Bellis; Giuseppe Maria Ettorre; Valentina Svicher; Roberto Santoro; Giovanni Vennarecci; Alessandra Biasiolo; Patrizia Pontisso; Daria Scacciatelli; Luca Beneduce; Cesare Sarrecchia; Paolo Casalino; Sergio Bernardini; Pasquale Pierimarchi; Enrico Garaci; Claudio Puoti; Guido Rasi

doi:10.1111/hepr.12239

Detection of high levels of Survivin-immunoglobulin M immune complex in sera from hepatitis C virus infected patients with cirrhosis

Claudia Matteucci, Roberta Sorrentino, Lia Bellis, Giuseppe Maria Ettorre, Valentina Svicher, Roberto Santoro, Giovanni Vennarecci, Alessandra Biasiolo, Patrizia Pontisso, Daria Scacciatelli, Luca Beneduce, Cesare Sarrecchia, Paolo Casalino, Sergio Bernardini, Pasquale Pierimarchi, Enrico Garaci, Claudio Puoti, Guido Rasi

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: The identification and surveillance of patients with liver dysfunctions and the discovering of new disease biomarkers are needed in the clinical practice. The aim of this study was to investigate on Survivin-immunoglobulin (Ig)M immune complex (IC) as a potential biomarker of chronic liver diseases. Methods: Serum levels of Survivin-IgM were measured using an enzyme-linked immunoassay that had been standardized and validated in our laboratory in 262 individuals, including healthy subjects and patients with chronic viral hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Results: Survivin-IgM IC was lower in healthy subjects (median, 99.39 AU/mL) than in patients with chronic viral hepatitis (median, 148.03 AU/mL; P=0.002) or with cirrhosis (median, 371.00 AU/mL; P

Original language	English
Pages (from-to)	1008-1018
Number of pages	11
Journal	Hepatology Research
Volume	44
Issue number	9
DOIs	https://doi.org/10.1111/hepr.12239
Publication status	Published - Sept 1 2014

Keywords

Disease biomarkers
Hepatitis C
Hepatocellular carcinoma
Immune complexes
Liver cirrhosis
Survivin

ASJC Scopus subject areas

Hepatology
Infectious Diseases

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10.1111/hepr.12239

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Matteucci, C., Sorrentino, R., Bellis, L., Ettorre, G. M., Svicher, V., Santoro, R., Vennarecci, G., Biasiolo, A., Pontisso, P., Scacciatelli, D., Beneduce, L., Sarrecchia, C., Casalino, P., Bernardini, S., Pierimarchi, P., Garaci, E., Puoti, C., & Rasi, G. (2014). Detection of high levels of Survivin-immunoglobulin M immune complex in sera from hepatitis C virus infected patients with cirrhosis. Hepatology Research, 44(9), 1008-1018. https://doi.org/10.1111/hepr.12239

Matteucci, C, Sorrentino, R, Bellis, L, Ettorre, GM, Svicher, V, Santoro, R, Vennarecci, G, Biasiolo, A, Pontisso, P, Scacciatelli, D, Beneduce, L, Sarrecchia, C, Casalino, P, Bernardini, S, Pierimarchi, P, Garaci, E, Puoti, C & Rasi, G 2014, 'Detection of high levels of Survivin-immunoglobulin M immune complex in sera from hepatitis C virus infected patients with cirrhosis', Hepatology Research, vol. 44, no. 9, pp. 1008-1018. https://doi.org/10.1111/hepr.12239

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AU - Ettorre, Giuseppe Maria

AU - Svicher, Valentina

AU - Santoro, Roberto

AU - Vennarecci, Giovanni

AU - Biasiolo, Alessandra

AU - Pontisso, Patrizia

AU - Scacciatelli, Daria

AU - Beneduce, Luca

AU - Sarrecchia, Cesare

AU - Casalino, Paolo

AU - Bernardini, Sergio

AU - Pierimarchi, Pasquale

AU - Garaci, Enrico

AU - Puoti, Claudio

AU - Rasi, Guido

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Detection of high levels of Survivin-immunoglobulin M immune complex in sera from hepatitis C virus infected patients with cirrhosis

Abstract

Keywords

ASJC Scopus subject areas

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