Detection of clustered circulating tumour cells in early breast cancer

Ilona Krol; Fabienne D. Schwab; Roberta Carbone; Mathilde Ritter; Sabrina Picocci; Marzia L. De Marni; Grazyna Stepien; Gian M. Franchi; Andrea Zanardi; Marco D. Rissoglio; Alfredo Covelli; Guido Guidi; Daniele Scarinci; Francesc Castro-Giner; Luca Mazzarella; Claudio Doglioni; Francesca Borghi; Paolo Milani; Christian Kurzeder; Walter P. Weber; Nicola Aceto

doi:10.1038/s41416-021-01327-8

Detection of clustered circulating tumour cells in early breast cancer

Ilona Krol, Fabienne D. Schwab, Roberta Carbone, Mathilde Ritter, Sabrina Picocci, Marzia L. De Marni, Grazyna Stepien, Gian M. Franchi, Andrea Zanardi, Marco D. Rissoglio, Alfredo Covelli, Guido Guidi, Daniele Scarinci, Francesc Castro-Giner, Luca Mazzarella, Claudio Doglioni, Francesca Borghi, Paolo Milani, Christian Kurzeder, Walter P. WeberNicola Aceto

Research output: Contribution to journal › Article › peer-review

Abstract

Circulating tumour cell (CTC) clusters have been proposed to be major players in the metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is unclear whether or not they manifest in early breast cancer, as their occurrence in patients with metastasis-free primary disease has not been thoroughly evaluated. In this study, exploiting nanostructured titanium oxide-coated slides for shear-free CTC identification, we detect clustered CTCs in the curative setting of multiple patients with early breast cancer prior to surgical treatment, highlighting their presence already at early disease stages. These results spotlight an important aspect of metastasis biology and the possibility to intervene with anti-cluster therapeutics already during the early manifestation of breast cancer.

Original language	English
Pages (from-to)	23-27
Number of pages	5
Journal	British Journal of Cancer
Volume	125
Issue number	1
DOIs	https://doi.org/10.1038/s41416-021-01327-8
Publication status	Published - Jul 6 2021

ASJC Scopus subject areas

Oncology
Cancer Research

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Krol, I., Schwab, F. D., Carbone, R., Ritter, M., Picocci, S., De Marni, M. L., Stepien, G., Franchi, G. M., Zanardi, A., Rissoglio, M. D., Covelli, A., Guidi, G., Scarinci, D., Castro-Giner, F., Mazzarella, L., Doglioni, C., Borghi, F., Milani, P., Kurzeder, C., ... Aceto, N. (2021). Detection of clustered circulating tumour cells in early breast cancer. British Journal of Cancer, 125(1), 23-27. https://doi.org/10.1038/s41416-021-01327-8

Krol, I, Schwab, FD, Carbone, R, Ritter, M, Picocci, S, De Marni, ML, Stepien, G, Franchi, GM, Zanardi, A, Rissoglio, MD, Covelli, A, Guidi, G, Scarinci, D, Castro-Giner, F, Mazzarella, L , Doglioni, C, Borghi, F, Milani, P, Kurzeder, C, Weber, WP & Aceto, N 2021, 'Detection of clustered circulating tumour cells in early breast cancer', British Journal of Cancer, vol. 125, no. 1, pp. 23-27. https://doi.org/10.1038/s41416-021-01327-8

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title = "Detection of clustered circulating tumour cells in early breast cancer",

abstract = "Circulating tumour cell (CTC) clusters have been proposed to be major players in the metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is unclear whether or not they manifest in early breast cancer, as their occurrence in patients with metastasis-free primary disease has not been thoroughly evaluated. In this study, exploiting nanostructured titanium oxide-coated slides for shear-free CTC identification, we detect clustered CTCs in the curative setting of multiple patients with early breast cancer prior to surgical treatment, highlighting their presence already at early disease stages. These results spotlight an important aspect of metastasis biology and the possibility to intervene with anti-cluster therapeutics already during the early manifestation of breast cancer.",

author = "Ilona Krol and Schwab, {Fabienne D.} and Roberta Carbone and Mathilde Ritter and Sabrina Picocci and {De Marni}, {Marzia L.} and Grazyna Stepien and Franchi, {Gian M.} and Andrea Zanardi and Rissoglio, {Marco D.} and Alfredo Covelli and Guido Guidi and Daniele Scarinci and Francesc Castro-Giner and Luca Mazzarella and Claudio Doglioni and Francesca Borghi and Paolo Milani and Christian Kurzeder and Weber, {Walter P.} and Nicola Aceto",

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doi = "10.1038/s41416-021-01327-8",

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AU - Krol, Ilona

AU - Schwab, Fabienne D.

AU - Carbone, Roberta

AU - Ritter, Mathilde

AU - Picocci, Sabrina

AU - De Marni, Marzia L.

AU - Stepien, Grazyna

AU - Franchi, Gian M.

AU - Zanardi, Andrea

AU - Rissoglio, Marco D.

AU - Covelli, Alfredo

AU - Guidi, Guido

AU - Scarinci, Daniele

AU - Castro-Giner, Francesc

AU - Mazzarella, Luca

AU - Doglioni, Claudio

AU - Borghi, Francesca

AU - Milani, Paolo

AU - Kurzeder, Christian

AU - Weber, Walter P.

AU - Aceto, Nicola

PY - 2021/7/6

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AB - Circulating tumour cell (CTC) clusters have been proposed to be major players in the metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is unclear whether or not they manifest in early breast cancer, as their occurrence in patients with metastasis-free primary disease has not been thoroughly evaluated. In this study, exploiting nanostructured titanium oxide-coated slides for shear-free CTC identification, we detect clustered CTCs in the curative setting of multiple patients with early breast cancer prior to surgical treatment, highlighting their presence already at early disease stages. These results spotlight an important aspect of metastasis biology and the possibility to intervene with anti-cluster therapeutics already during the early manifestation of breast cancer.

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Detection of clustered circulating tumour cells in early breast cancer

Abstract

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