Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

G. Gargano; V. Agnese; V. Calò; S. Corsale; C. Augello; L. Bruno; L. La Paglia; A. Gullo; L. Ottini; A. Russo; F. Fulfaro; G. Rinaldi; A. Crosta; G. Cicero; O. Majorana; L. Palmeri; C. Cipolla; A. Agrusa; G. Gulotta; V. Morello; G. Di Fede; V. Adamo; G. Colucci; R. M. Tomasino; M. R. Valerio; V. Bazan; Antonio Russo

doi:10.1093/annonc/mdl948

Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

G. Gargano, V. Agnese, V. Calò, S. Corsale, C. Augello, L. Bruno, L. La Paglia, A. Gullo, L. Ottini, A. Russo, F. Fulfaro, G. Rinaldi, A. Crosta, G. Cicero, O. Majorana, L. Palmeri, C. Cipolla, A. Agrusa, G. Gulotta, V. MorelloG. Di Fede, V. Adamo, G. Colucci, R. M. Tomasino, M. R. Valerio, V. Bazan, Antonio Russo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Mammaglobin is expressed mainly in mammary tissue, overexpressed in breast cancer (BC) and rarely in other tissue. The aim of this study was to assess the sensitivity and specificity of transcript MGB1 detection and to evaluate the role of MGB1 as potential clinical marker for the detection of disseminated cancer cells in the blood of BC patients. Patients and methods: A consecutive series of 23 BC tissues, 36 peripheral blood BC samples and 35 healthy peripheral blood samples was prospectively recruited to investigate MGB1 expression by means of a quantitative Real Time RT-PCR assay. Results: MGB1 overexpression in tissue samples of BC patients is significantly associated only with high level of Ki67 (P

Original language	English
Journal	Annals of Oncology
Volume	17
Issue number	SUPPL. 7
DOIs	https://doi.org/10.1093/annonc/mdl948
Publication status	Published - Jun 2006

Keywords

Breast cancer
Disseminated cancer cells
Mammaglobin (MGB1)
Real time RT-PCR

ASJC Scopus subject areas

Oncology
Cancer Research

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Gargano, G., Agnese, V., Calò, V., Corsale, S., Augello, C., Bruno, L., La Paglia, L., Gullo, A., Ottini, L., Russo, A., Fulfaro, F., Rinaldi, G., Crosta, A., Cicero, G., Majorana, O., Palmeri, L., Cipolla, C., Agrusa, A., Gulotta, G., ... Russo, A. (2006). Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. Annals of Oncology, 17(SUPPL. 7). https://doi.org/10.1093/annonc/mdl948

Detection and quantification of mammaglobin in the blood of breast cancer patients : Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. / Gargano, G.; Agnese, V.; Calò, V. et al.

In: Annals of Oncology, Vol. 17, No. SUPPL. 7, 06.2006.

Research output: Contribution to journal › Article › peer-review

Gargano, G, Agnese, V, Calò, V, Corsale, S, Augello, C, Bruno, L, La Paglia, L, Gullo, A, Ottini, L, Russo, A, Fulfaro, F, Rinaldi, G, Crosta, A, Cicero, G, Majorana, O, Palmeri, L, Cipolla, C, Agrusa, A, Gulotta, G, Morello, V, Di Fede, G, Adamo, V, Colucci, G, Tomasino, RM, Valerio, MR, Bazan, V & Russo, A 2006, 'Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study', Annals of Oncology, vol. 17, no. SUPPL. 7. https://doi.org/10.1093/annonc/mdl948

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title = "Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study",

abstract = "Background: Mammaglobin is expressed mainly in mammary tissue, overexpressed in breast cancer (BC) and rarely in other tissue. The aim of this study was to assess the sensitivity and specificity of transcript MGB1 detection and to evaluate the role of MGB1 as potential clinical marker for the detection of disseminated cancer cells in the blood of BC patients. Patients and methods: A consecutive series of 23 BC tissues, 36 peripheral blood BC samples and 35 healthy peripheral blood samples was prospectively recruited to investigate MGB1 expression by means of a quantitative Real Time RT-PCR assay. Results: MGB1 overexpression in tissue samples of BC patients is significantly associated only with high level of Ki67 (P ",

keywords = "Breast cancer, Disseminated cancer cells, Mammaglobin (MGB1), Real time RT-PCR",

author = "G. Gargano and V. Agnese and V. Cal{\`o} and S. Corsale and C. Augello and L. Bruno and {La Paglia}, L. and A. Gullo and L. Ottini and A. Russo and F. Fulfaro and G. Rinaldi and A. Crosta and G. Cicero and O. Majorana and L. Palmeri and C. Cipolla and A. Agrusa and G. Gulotta and V. Morello and {Di Fede}, G. and V. Adamo and G. Colucci and Tomasino, {R. M.} and Valerio, {M. R.} and V. Bazan and Antonio Russo",

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doi = "10.1093/annonc/mdl948",

language = "English",

volume = "17",

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T1 - Detection and quantification of mammaglobin in the blood of breast cancer patients

T2 - Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

AU - Gargano, G.

AU - Agnese, V.

AU - Calò, V.

AU - Corsale, S.

AU - Augello, C.

AU - Bruno, L.

AU - La Paglia, L.

AU - Gullo, A.

AU - Ottini, L.

AU - Russo, A.

AU - Fulfaro, F.

AU - Rinaldi, G.

AU - Crosta, A.

AU - Cicero, G.

AU - Majorana, O.

AU - Palmeri, L.

AU - Cipolla, C.

AU - Agrusa, A.

AU - Gulotta, G.

AU - Morello, V.

AU - Di Fede, G.

AU - Adamo, V.

AU - Colucci, G.

AU - Tomasino, R. M.

AU - Valerio, M. R.

AU - Bazan, V.

AU - Russo, Antonio

PY - 2006/6

Y1 - 2006/6

N2 - Background: Mammaglobin is expressed mainly in mammary tissue, overexpressed in breast cancer (BC) and rarely in other tissue. The aim of this study was to assess the sensitivity and specificity of transcript MGB1 detection and to evaluate the role of MGB1 as potential clinical marker for the detection of disseminated cancer cells in the blood of BC patients. Patients and methods: A consecutive series of 23 BC tissues, 36 peripheral blood BC samples and 35 healthy peripheral blood samples was prospectively recruited to investigate MGB1 expression by means of a quantitative Real Time RT-PCR assay. Results: MGB1 overexpression in tissue samples of BC patients is significantly associated only with high level of Ki67 (P

AB - Background: Mammaglobin is expressed mainly in mammary tissue, overexpressed in breast cancer (BC) and rarely in other tissue. The aim of this study was to assess the sensitivity and specificity of transcript MGB1 detection and to evaluate the role of MGB1 as potential clinical marker for the detection of disseminated cancer cells in the blood of BC patients. Patients and methods: A consecutive series of 23 BC tissues, 36 peripheral blood BC samples and 35 healthy peripheral blood samples was prospectively recruited to investigate MGB1 expression by means of a quantitative Real Time RT-PCR assay. Results: MGB1 overexpression in tissue samples of BC patients is significantly associated only with high level of Ki67 (P

KW - Breast cancer

KW - Disseminated cancer cells

KW - Mammaglobin (MGB1)

KW - Real time RT-PCR

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Detection and quantification of mammaglobin in the blood of breast cancer patients: Can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

Abstract

Keywords

ASJC Scopus subject areas

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