Demographic and geographic vascular risk factor differences in european young adults with ischemic stroke: The 15 cities young stroke study

Jukka Putaala, Nilufer Yesilot, Ulrike Waje-Andreassen, Janne Pitkäniemi, Sofia Vassilopoulou, Katiuscia Nardi, Celine Odier, Gergely Hofgart, Stefan Engelter, Annika Burow, Laszlo Mihalka, Manja Kloss, Julia Ferrari, Robin Lemmens, Oguzhan Coban, Elena Haapaniemi, Noortje Maaijwee, Loes Rutten-Jacobs, Anna Bersano, Carlo CeredaPierluigi Baron, Linda Borellini, Caterina Valcarenghi, Lars Thomassen, Armin J. Grau, Frederick Palm, Christian Urbanek, Rezzan Tuncay, Aysan Durukan-Tolvanen, Ewoud J. Van Dijk, Frank Erik De Leeuw, Vincent Thijs, Stefan Greisenegger, Konstantinos Vemmos, Christoph Lichy, Daniel Bereczki, Laszlo Csiba, Patrik Michel, Didier Leys, Konstantinos Spengos, Halvor Naess, Sara Zarko Bahar, Turgut Tatlisumak

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND PURPOSE-: We compared among young patients with ischemic stroke the distribution of vascular risk factors among sex, age groups, and 3 distinct geographic regions in Europe. METHODS-: We included patients with first-ever ischemic stroke aged 15 to 49 years from existing hospital- or population-based prospective or consecutive young stroke registries involving 15 cities in 12 countries. Geographic regions were defined as northern (Finland, Norway), central (Austria, Belgium, France, Germany, Hungary, The Netherlands, Switzerland), and southern (Greece, Italy, Turkey) Europe. Hierarchical regression models were used for comparisons. RESULTS-: In the study cohort (n=3944), the 3 most frequent risk factors were current smoking (48.7%), dyslipidemia (45.8%), and hypertension (35.9%). Compared with central (n=1868; median age, 43 years) and northern (n=1330; median age, 44 years) European patients, southern Europeans (n=746; median age, 41 years) were younger. No sex difference emerged between the regions, male:female ratio being 0.7 in those aged

Original languageEnglish
Pages (from-to)2624-2630
Number of pages7
Issue number10
Publication statusPublished - Oct 2012


  • cerebral infarct
  • ischemic stroke
  • risk factors
  • stroke in young adults

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing


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