TY - JOUR
T1 - Definition by CB12 monoclonal antibody of a differentiation marker specific for human monocytes and their bone marrow precursors
AU - Malavasi, F.
AU - Funaro, A.
AU - Bellone, G.
AU - Caligaris-Cappio, F.
AU - Semenzato, G.
AU - Cappa, A. P M
AU - Ferrero, E.
AU - Novelli, F.
AU - Alessio, M.
AU - Demaria, S.
AU - Dellabona, P.
PY - 1986
Y1 - 1986
N2 - The CB12 monoclonal antibody, which reacts with a molecule expressed on monocytes, was characterized using human embryonic material as immunizer. Analysis of the monoclonal antibody at the phenotypic, molecular, and functional levels indicates that its reactivity is restricted to circulating monocytes and their precursors in the bone marrow, whereas it is undetectable on tissue macrophages. CB12 displays a pattern of reactivity compatible with that of a marker of monocyte differentiation. Preliminary data indicate a possible receptor role for the CB12 molecule.
AB - The CB12 monoclonal antibody, which reacts with a molecule expressed on monocytes, was characterized using human embryonic material as immunizer. Analysis of the monoclonal antibody at the phenotypic, molecular, and functional levels indicates that its reactivity is restricted to circulating monocytes and their precursors in the bone marrow, whereas it is undetectable on tissue macrophages. CB12 displays a pattern of reactivity compatible with that of a marker of monocyte differentiation. Preliminary data indicate a possible receptor role for the CB12 molecule.
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U2 - 10.1016/0008-8749(86)90398-9
DO - 10.1016/0008-8749(86)90398-9
M3 - Article
C2 - 3091273
AN - SCOPUS:0022655665
SN - 0008-8749
VL - 97
SP - 276
EP - 285
JO - Cellular Immunology
JF - Cellular Immunology
IS - 2
ER -