Deficit of pursuit ocular movements in early alzheimer's disease

Francesco Cordici, Pietro Lanzafame, Silvia Marino, Alessandro Celona, Lilla Bonanno, Annalisa Baglieri, Alessia Bramanti, Placido Bramanti

Research output: Contribution to journalArticlepeer-review


Previous studies have demonstrated that advanced Alzheimer's disease (AD) patients have deficiency of eye movements. However, there have been no reports on eye movement in the early stages of AD. The aim of this study was to evaluate pursuit ocular movements (POM) provided by a vision-based non-intrusive eye tracker in patients with early AD. POM values were significantly lower in AD patients than in normal controls (P <0.01). In AD patients, POM values were not closely correlated with the Mini-Mental State Examination scores (P = 0.3). There was no significant difference in POM values among patients treated with or without anticholinesterase therapy. We used a vision-based method, for non-intrusive eye tracking, which can be proposed as a possible tool for supporting the diagnosis of early AD.

Original languageEnglish
Pages (from-to)1583-1586
Number of pages4
JournalNeural Regeneration Research
Issue number20
Publication statusPublished - Oct 2010


  • Alzheimer's disease
  • Early diagnosis
  • Pursuit ocular movements
  • Smooth pursuit dysfunctions
  • Vision-based eye tracking system

ASJC Scopus subject areas

  • Developmental Neuroscience


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