Deficit of pursuit ocular movements in early alzheimer's disease

Francesco Cordici; Pietro Lanzafame; Silvia Marino; Alessandro Celona; Lilla Bonanno; Annalisa Baglieri; Alessia Bramanti; Placido Bramanti

doi:10.3969/j.issn.1673-5374.2010.20.011

Deficit of pursuit ocular movements in early alzheimer's disease

Francesco Cordici, Pietro Lanzafame, Silvia Marino, Alessandro Celona, Lilla Bonanno, Annalisa Baglieri, Alessia Bramanti, Placido Bramanti

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies have demonstrated that advanced Alzheimer's disease (AD) patients have deficiency of eye movements. However, there have been no reports on eye movement in the early stages of AD. The aim of this study was to evaluate pursuit ocular movements (POM) provided by a vision-based non-intrusive eye tracker in patients with early AD. POM values were significantly lower in AD patients than in normal controls (P <0.01). In AD patients, POM values were not closely correlated with the Mini-Mental State Examination scores (P = 0.3). There was no significant difference in POM values among patients treated with or without anticholinesterase therapy. We used a vision-based method, for non-intrusive eye tracking, which can be proposed as a possible tool for supporting the diagnosis of early AD.

Original language	English
Pages (from-to)	1583-1586
Number of pages	4
Journal	Neural Regeneration Research
Volume	5
Issue number	20
DOIs	https://doi.org/10.3969/j.issn.1673-5374.2010.20.011
Publication status	Published - Oct 2010

Keywords

Alzheimer's disease
Early diagnosis
Pursuit ocular movements
Smooth pursuit dysfunctions
Vision-based eye tracking system

ASJC Scopus subject areas

Developmental Neuroscience

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10.3969/j.issn.1673-5374.2010.20.011

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title = "Deficit of pursuit ocular movements in early alzheimer's disease",

abstract = "Previous studies have demonstrated that advanced Alzheimer's disease (AD) patients have deficiency of eye movements. However, there have been no reports on eye movement in the early stages of AD. The aim of this study was to evaluate pursuit ocular movements (POM) provided by a vision-based non-intrusive eye tracker in patients with early AD. POM values were significantly lower in AD patients than in normal controls (P <0.01). In AD patients, POM values were not closely correlated with the Mini-Mental State Examination scores (P = 0.3). There was no significant difference in POM values among patients treated with or without anticholinesterase therapy. We used a vision-based method, for non-intrusive eye tracking, which can be proposed as a possible tool for supporting the diagnosis of early AD.",

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author = "Francesco Cordici and Pietro Lanzafame and Silvia Marino and Alessandro Celona and Lilla Bonanno and Annalisa Baglieri and Alessia Bramanti and Placido Bramanti",

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AU - Cordici, Francesco

AU - Lanzafame, Pietro

AU - Marino, Silvia

AU - Celona, Alessandro

AU - Bonanno, Lilla

AU - Baglieri, Annalisa

AU - Bramanti, Alessia

AU - Bramanti, Placido

PY - 2010/10

Y1 - 2010/10

N2 - Previous studies have demonstrated that advanced Alzheimer's disease (AD) patients have deficiency of eye movements. However, there have been no reports on eye movement in the early stages of AD. The aim of this study was to evaluate pursuit ocular movements (POM) provided by a vision-based non-intrusive eye tracker in patients with early AD. POM values were significantly lower in AD patients than in normal controls (P <0.01). In AD patients, POM values were not closely correlated with the Mini-Mental State Examination scores (P = 0.3). There was no significant difference in POM values among patients treated with or without anticholinesterase therapy. We used a vision-based method, for non-intrusive eye tracking, which can be proposed as a possible tool for supporting the diagnosis of early AD.

AB - Previous studies have demonstrated that advanced Alzheimer's disease (AD) patients have deficiency of eye movements. However, there have been no reports on eye movement in the early stages of AD. The aim of this study was to evaluate pursuit ocular movements (POM) provided by a vision-based non-intrusive eye tracker in patients with early AD. POM values were significantly lower in AD patients than in normal controls (P <0.01). In AD patients, POM values were not closely correlated with the Mini-Mental State Examination scores (P = 0.3). There was no significant difference in POM values among patients treated with or without anticholinesterase therapy. We used a vision-based method, for non-intrusive eye tracking, which can be proposed as a possible tool for supporting the diagnosis of early AD.

KW - Alzheimer's disease

KW - Early diagnosis

KW - Pursuit ocular movements

KW - Smooth pursuit dysfunctions

KW - Vision-based eye tracking system

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Deficit of pursuit ocular movements in early alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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