Defective Fas ligand production in lymphocytes from MS patients

Beatrice Macchi; Claudia Matteucci; Ugo Nocentini; Santina Tacconi; Veronica Pagnini; Antonio Mastino; Carlo Caltagirone

Defective Fas ligand production in lymphocytes from MS patients

Beatrice Macchi, Claudia Matteucci, Ugo Nocentini, Santina Tacconi, Veronica Pagnini, Antonio Mastino, Carlo Caltagirone

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

In the present transectional study, Fas ligand (Fas-L) levels, either in membrane or in soluble form, in cells from multiple sclerosis (MS) patients were investigated. Expression of Fas was evaluated after PHA stimulation of peripheral blood mononuclear cells from MS patients with relapsing-remitting or secondary-progressive disease, and in healthy donors. There was statistically significant decreased expression (p = 0.001), as well as release of Fas-L, (p = 0.045) in lymphocytes from MS patients, in comparison with healthy donors. Moreover, levels of Fas-L production were inversely correlated with the EDSS scores of patients in an highly significant way. Impairment of Fas-L release in stimulated PBMC from MS patients might influence the ability to eliminate autoreactive clones in vivo.

Original language	English
Pages (from-to)	4113-4116
Number of pages	4
Journal	NeuroReport
Volume	12
Issue number	18
Publication status	Published - Dec 21 2001

Keywords

Apoptosis
EDSS
Fas ligand
Lymphocytes
Multiple sclerosis

ASJC Scopus subject areas

Neuroscience(all)

Cite this

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abstract = "In the present transectional study, Fas ligand (Fas-L) levels, either in membrane or in soluble form, in cells from multiple sclerosis (MS) patients were investigated. Expression of Fas was evaluated after PHA stimulation of peripheral blood mononuclear cells from MS patients with relapsing-remitting or secondary-progressive disease, and in healthy donors. There was statistically significant decreased expression (p = 0.001), as well as release of Fas-L, (p = 0.045) in lymphocytes from MS patients, in comparison with healthy donors. Moreover, levels of Fas-L production were inversely correlated with the EDSS scores of patients in an highly significant way. Impairment of Fas-L release in stimulated PBMC from MS patients might influence the ability to eliminate autoreactive clones in vivo.",

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T1 - Defective Fas ligand production in lymphocytes from MS patients

AU - Macchi, Beatrice

AU - Matteucci, Claudia

AU - Nocentini, Ugo

AU - Tacconi, Santina

AU - Pagnini, Veronica

AU - Mastino, Antonio

AU - Caltagirone, Carlo

PY - 2001/12/21

Y1 - 2001/12/21

N2 - In the present transectional study, Fas ligand (Fas-L) levels, either in membrane or in soluble form, in cells from multiple sclerosis (MS) patients were investigated. Expression of Fas was evaluated after PHA stimulation of peripheral blood mononuclear cells from MS patients with relapsing-remitting or secondary-progressive disease, and in healthy donors. There was statistically significant decreased expression (p = 0.001), as well as release of Fas-L, (p = 0.045) in lymphocytes from MS patients, in comparison with healthy donors. Moreover, levels of Fas-L production were inversely correlated with the EDSS scores of patients in an highly significant way. Impairment of Fas-L release in stimulated PBMC from MS patients might influence the ability to eliminate autoreactive clones in vivo.

AB - In the present transectional study, Fas ligand (Fas-L) levels, either in membrane or in soluble form, in cells from multiple sclerosis (MS) patients were investigated. Expression of Fas was evaluated after PHA stimulation of peripheral blood mononuclear cells from MS patients with relapsing-remitting or secondary-progressive disease, and in healthy donors. There was statistically significant decreased expression (p = 0.001), as well as release of Fas-L, (p = 0.045) in lymphocytes from MS patients, in comparison with healthy donors. Moreover, levels of Fas-L production were inversely correlated with the EDSS scores of patients in an highly significant way. Impairment of Fas-L release in stimulated PBMC from MS patients might influence the ability to eliminate autoreactive clones in vivo.

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KW - EDSS

KW - Fas ligand

KW - Lymphocytes

KW - Multiple sclerosis

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Defective Fas ligand production in lymphocytes from MS patients

Abstract

Keywords

ASJC Scopus subject areas

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