D-Luciferin, derivatives and analogues: Synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity

Giuseppe Meroni; Mehdi Rajabi; Enzo Santaniello

D-Luciferin, derivatives and analogues: Synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity

Giuseppe Meroni, Mehdi Rajabi, Enzo Santaniello

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

D-luciferin is the natural substrate of all luciferases that catalyze the production of light in bioluminescent insects. The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging.

Original language	English
Pages (from-to)	265-288
Number of pages	24
Journal	Arkivoc
Volume	2009
Issue number	1
Publication status	Published - Feb 21 2009

Keywords

Bioluminescence
D-luciferin
Luciferase
Optical imaging
Synthesis

ASJC Scopus subject areas

Organic Chemistry

Cite this

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abstract = "D-luciferin is the natural substrate of all luciferases that catalyze the production of light in bioluminescent insects. The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging.",

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AU - Meroni, Giuseppe

AU - Rajabi, Mehdi

AU - Santaniello, Enzo

PY - 2009/2/21

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N2 - D-luciferin is the natural substrate of all luciferases that catalyze the production of light in bioluminescent insects. The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging.

AB - D-luciferin is the natural substrate of all luciferases that catalyze the production of light in bioluminescent insects. The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging.

KW - Bioluminescence

KW - D-luciferin

KW - Luciferase

KW - Optical imaging

KW - Synthesis

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D-Luciferin, derivatives and analogues: Synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity

Abstract

Keywords

ASJC Scopus subject areas

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