Cytomegalovirus (AD169) infection in human chondrocyte cell cultures.

A. M. Patti; A. Vulcano; A. Gabriele; C. Della Rocca

Cytomegalovirus (AD169) infection in human chondrocyte cell cultures.

A. M. Patti, A. Vulcano, A. Gabriele, C. Della Rocca

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Human chondrocytes are susceptible to productive human cytomegalovirus (HCMV, AD169 strain) infection. Infection of chondrocytes resulted in pronounced cytopathic effects including cell rounding and aggregation, fusions, and lysis. Immunohistochemical staining reveals that a portion of chondrocytes expressed antigens reactive to monoclonal antibodies against early HCMV proteins. The interaction of HCMV with cartilage cells may be one key for elucidating the etiopathogenesis of articular diseases.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Annali di igiene : medicina preventiva e di comunità
Volume	19
Issue number	3
Publication status	Published - May 2007

ASJC Scopus subject areas

Medicine(all)

Cite this

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abstract = "Human chondrocytes are susceptible to productive human cytomegalovirus (HCMV, AD169 strain) infection. Infection of chondrocytes resulted in pronounced cytopathic effects including cell rounding and aggregation, fusions, and lysis. Immunohistochemical staining reveals that a portion of chondrocytes expressed antigens reactive to monoclonal antibodies against early HCMV proteins. The interaction of HCMV with cartilage cells may be one key for elucidating the etiopathogenesis of articular diseases.",

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AB - Human chondrocytes are susceptible to productive human cytomegalovirus (HCMV, AD169 strain) infection. Infection of chondrocytes resulted in pronounced cytopathic effects including cell rounding and aggregation, fusions, and lysis. Immunohistochemical staining reveals that a portion of chondrocytes expressed antigens reactive to monoclonal antibodies against early HCMV proteins. The interaction of HCMV with cartilage cells may be one key for elucidating the etiopathogenesis of articular diseases.

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Cytomegalovirus (AD169) infection in human chondrocyte cell cultures.

Abstract

ASJC Scopus subject areas

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