TY - JOUR
T1 - Cytological and Immunocytochemical Features of Merkel Cell Carcinoma on Fine Needle Cytology Samples
T2 - A Study of 22 Cases
AU - Cipolletta Campanile, Anna
AU - Malzone, Maria Gabriella
AU - Sanna, Veronica
AU - Barizzi, Jessica
AU - Manna, Angela
AU - Gioioso, Antonella
AU - De Chiara, Annarosaria
AU - Fulciniti, Franco
PY - 2015/9/6
Y1 - 2015/9/6
N2 - Merkel cell carcinoma (MCC) is an uncommon neuroendocrine small cell tumor derived from the transformation of the homonymous cells in the basal layer of the epidermis. MCC has a generally aggressive course, with a high tendency for local recurrence, lymph node involvement, and distant metastasis. Fine needle cytology (FNC) and immunocytochemistry were used as diagnostic procedures for 22 cases of MCC presented at our institute. All cases of MCC were successfully diagnosed on FNC. Among all of the monoclonal antisera used (CD56, CK20, CK MNF116, neuron-specific enolase (NSE), synaptophysin, and chromogranin), NSE and CD56 showed the highest frequency of positivity. The accuracy of the cytological diagnosis was 100 % compared to the corresponding previous or subsequent pathological diagnoses. FNC and immunocytochemistry represent excellent and accurate diagnostic methods to distinguish MCC from other small-cell malignant entities.
AB - Merkel cell carcinoma (MCC) is an uncommon neuroendocrine small cell tumor derived from the transformation of the homonymous cells in the basal layer of the epidermis. MCC has a generally aggressive course, with a high tendency for local recurrence, lymph node involvement, and distant metastasis. Fine needle cytology (FNC) and immunocytochemistry were used as diagnostic procedures for 22 cases of MCC presented at our institute. All cases of MCC were successfully diagnosed on FNC. Among all of the monoclonal antisera used (CD56, CK20, CK MNF116, neuron-specific enolase (NSE), synaptophysin, and chromogranin), NSE and CD56 showed the highest frequency of positivity. The accuracy of the cytological diagnosis was 100 % compared to the corresponding previous or subsequent pathological diagnoses. FNC and immunocytochemistry represent excellent and accurate diagnostic methods to distinguish MCC from other small-cell malignant entities.
KW - Fine needle cytology
KW - Immunocytochemistry
KW - Merkel cell carcinoma
KW - Neuroendocrine tumor
UR - http://www.scopus.com/inward/record.url?scp=84938743514&partnerID=8YFLogxK
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U2 - 10.1007/s12022-015-9375-6
DO - 10.1007/s12022-015-9375-6
M3 - Article
C2 - 25982258
AN - SCOPUS:84938743514
SN - 1046-3976
VL - 26
SP - 243
EP - 249
JO - Endocrine Pathology
JF - Endocrine Pathology
IS - 3
ER -