Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea

Luigina Guasti; Franca Marino; Marco Cosentino; Lorenzo Maroni; Andrea M. Maresca; Fausto Colombo; Ramona C. Maio; Luana Castiglioni; Federica Saporiti; Anna Loraschi; Giovanni Gaudio; Antonella Bernasconi; Emanuela Laurita; Anna M. Grandi; Achille Venco

doi:10.1007/s11325-009-0315-x

Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea

Luigina Guasti, Franca Marino, Marco Cosentino, Lorenzo Maroni, Andrea M. Maresca, Fausto Colombo, Ramona C. Maio, Luana Castiglioni, Federica Saporiti, Anna Loraschi, Giovanni Gaudio, Antonella Bernasconi, Emanuela Laurita, Anna M. Grandi, Achille Venco

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: The relationship between obstructive sleep apnea (OSA) and atherosclerosis-related inflammation has been poorly investigated, particularly focusing on functional responses of immune cells playing a key role in atherogenesis and in comparison with control groups with similar cardiovascular risk factors which are known to be themselves associated with inflammation. We sought to determine cellular tumor necrosis factor-alpha (TNF-α) production from peripheral blood mononuclear cells (PBMCs) and interleukin (IL)-8 release from neutrophils (PMNs) in patients studied for suspected OSA. Methods: Thirty-six consecutive patients who underwent a nocturnal complete cardiorespiratory evaluation for suspected OSA were initially evaluated. Serum, PBMCs, and PMNs were isolated (at baseline and after 12 weeks) from patients with apnea-ipopnea index (AHI) >20 (OSA group, n=16) and from control patients with AHI

Original language	English
Pages (from-to)	3-11
Number of pages	9
Journal	Sleep and Breathing
Volume	15
Issue number	1
DOIs	https://doi.org/10.1007/s11325-009-0315-x
Publication status	Published - Jan 2011

Keywords

Continuous positive airway pressure ventilation
Interleukin-8
Obstructive sleep apnea
Peripheral blood mononuclear cells
Polymorphonuclear leukocytes
Tumor necrosis factor-α

ASJC Scopus subject areas

Otorhinolaryngology
Clinical Neurology

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Guasti, L., Marino, F., Cosentino, M., Maroni, L., Maresca, A. M., Colombo, F., Maio, R. C., Castiglioni, L., Saporiti, F., Loraschi, A., Gaudio, G., Bernasconi, A., Laurita, E., Grandi, A. M., & Venco, A. (2011). Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea. Sleep and Breathing, 15(1), 3-11. https://doi.org/10.1007/s11325-009-0315-x

Guasti, L, Marino, F, Cosentino, M, Maroni, L, Maresca, AM, Colombo, F, Maio, RC, Castiglioni, L, Saporiti, F, Loraschi, A, Gaudio, G, Bernasconi, A, Laurita, E, Grandi, AM & Venco, A 2011, 'Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea', Sleep and Breathing, vol. 15, no. 1, pp. 3-11. https://doi.org/10.1007/s11325-009-0315-x

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title = "Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea",

abstract = "Purpose: The relationship between obstructive sleep apnea (OSA) and atherosclerosis-related inflammation has been poorly investigated, particularly focusing on functional responses of immune cells playing a key role in atherogenesis and in comparison with control groups with similar cardiovascular risk factors which are known to be themselves associated with inflammation. We sought to determine cellular tumor necrosis factor-alpha (TNF-α) production from peripheral blood mononuclear cells (PBMCs) and interleukin (IL)-8 release from neutrophils (PMNs) in patients studied for suspected OSA. Methods: Thirty-six consecutive patients who underwent a nocturnal complete cardiorespiratory evaluation for suspected OSA were initially evaluated. Serum, PBMCs, and PMNs were isolated (at baseline and after 12 weeks) from patients with apnea-ipopnea index (AHI) >20 (OSA group, n=16) and from control patients with AHI ",

keywords = "Continuous positive airway pressure ventilation, Interleukin-8, Obstructive sleep apnea, Peripheral blood mononuclear cells, Polymorphonuclear leukocytes, Tumor necrosis factor-α",

author = "Luigina Guasti and Franca Marino and Marco Cosentino and Lorenzo Maroni and Maresca, {Andrea M.} and Fausto Colombo and Maio, {Ramona C.} and Luana Castiglioni and Federica Saporiti and Anna Loraschi and Giovanni Gaudio and Antonella Bernasconi and Emanuela Laurita and Grandi, {Anna M.} and Achille Venco",

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doi = "10.1007/s11325-009-0315-x",

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AU - Guasti, Luigina

AU - Marino, Franca

AU - Cosentino, Marco

AU - Maroni, Lorenzo

AU - Maresca, Andrea M.

AU - Colombo, Fausto

AU - Maio, Ramona C.

AU - Castiglioni, Luana

AU - Saporiti, Federica

AU - Loraschi, Anna

AU - Gaudio, Giovanni

AU - Bernasconi, Antonella

AU - Laurita, Emanuela

AU - Grandi, Anna M.

AU - Venco, Achille

PY - 2011/1

Y1 - 2011/1

N2 - Purpose: The relationship between obstructive sleep apnea (OSA) and atherosclerosis-related inflammation has been poorly investigated, particularly focusing on functional responses of immune cells playing a key role in atherogenesis and in comparison with control groups with similar cardiovascular risk factors which are known to be themselves associated with inflammation. We sought to determine cellular tumor necrosis factor-alpha (TNF-α) production from peripheral blood mononuclear cells (PBMCs) and interleukin (IL)-8 release from neutrophils (PMNs) in patients studied for suspected OSA. Methods: Thirty-six consecutive patients who underwent a nocturnal complete cardiorespiratory evaluation for suspected OSA were initially evaluated. Serum, PBMCs, and PMNs were isolated (at baseline and after 12 weeks) from patients with apnea-ipopnea index (AHI) >20 (OSA group, n=16) and from control patients with AHI

AB - Purpose: The relationship between obstructive sleep apnea (OSA) and atherosclerosis-related inflammation has been poorly investigated, particularly focusing on functional responses of immune cells playing a key role in atherogenesis and in comparison with control groups with similar cardiovascular risk factors which are known to be themselves associated with inflammation. We sought to determine cellular tumor necrosis factor-alpha (TNF-α) production from peripheral blood mononuclear cells (PBMCs) and interleukin (IL)-8 release from neutrophils (PMNs) in patients studied for suspected OSA. Methods: Thirty-six consecutive patients who underwent a nocturnal complete cardiorespiratory evaluation for suspected OSA were initially evaluated. Serum, PBMCs, and PMNs were isolated (at baseline and after 12 weeks) from patients with apnea-ipopnea index (AHI) >20 (OSA group, n=16) and from control patients with AHI

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Cytokine production from peripheral blood mononuclear cells and polymorphonuclear leukocytes in patients studied for suspected obstructive sleep apnea

Abstract

Keywords

ASJC Scopus subject areas

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