Cytogenetic studies in primary and metastatic neuroendocrine merkel cell carcinoma

Gabriella Sozzi, Maria Grazia Bertoglio, Silvana Pilotti, Franco Rilke, Marco A. Pierotti, Giuseppe Della Porta

Research output: Contribution to journalArticlepeer-review


Direct preparations of five primary and metastatic neuroendocrine Merkel cell carcinomas of the skin were analyzed using a G-banding technique. A recurrent structural abnormality was a rearranged chromosome #1 with involvement of p and q arms. In two cases this rearrangement appeared as a unique structural cytogenetic change. Evidence for clonal origin and karyotypic stability of this tumor was suggested by the occurrence of the same karyotypic changes in two metachronous metastases and in primary and metastatic tumor specimens of two different patients. The bands involved in rearrangements could be of significance in the molecular process of the neoplastic transformation of Merkel tumor because genes relevant to the differentiation of neural crest-derived tissue have been mapped in those regions.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalCancer Genetics and Cytogenetics
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology


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