TY - JOUR
T1 - Cutting edge
T2 - Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties
AU - Sozzani, Silvano
AU - Allavena, Paola
AU - D'Amico, Giovanna
AU - Luini, Walter
AU - Blanchi, Giancarlo
AU - Kataura, Motoji
AU - Imai, Toshio
AU - Yoshie, Osamu
AU - Bonecchi, Raffaella
AU - Mantovani, Alberto
PY - 1998/8/1
Y1 - 1998/8/1
N2 - Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present Ag. CC chemokines induce chemotactic and transendothelial migration of immature DC, in vitro. Maturation of DC by CD40L, or by LPS, IL-1, and TNF, induces down- regulation of the two main CC chemokine receptors expressed by these cells, CCR1 and CCR5, and abrogates chemotaxis to their ligands. Inhibition was rapid (
AB - Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present Ag. CC chemokines induce chemotactic and transendothelial migration of immature DC, in vitro. Maturation of DC by CD40L, or by LPS, IL-1, and TNF, induces down- regulation of the two main CC chemokine receptors expressed by these cells, CCR1 and CCR5, and abrogates chemotaxis to their ligands. Inhibition was rapid (
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M3 - Article
C2 - 9686565
AN - SCOPUS:0032134302
SN - 0022-1767
VL - 161
SP - 1083
EP - 1086
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -