Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?

Valentina Marchica; Fabrizio Accardi; Paola Storti; Cristina Mancini; Eugenia Martella; Benedetta Dalla Palma; Marina Bolzoni; Katia Todoerti; Magda Marcatti; Chiara Schifano; Sabrina Bonomini; Gabriella Sammarelli; Antonino Neri; Maurilio Ponzoni; Franco Aversa; Nicola Giuliani

doi:10.1007/s12185-016-2104-1

Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?

Valentina Marchica, Fabrizio Accardi, Paola Storti, Cristina Mancini, Eugenia Martella, Benedetta Dalla Palma, Marina Bolzoni, Katia Todoerti, Magda Marcatti, Chiara Schifano, Sabrina Bonomini, Gabriella Sammarelli, Antonino Neri, Maurilio Ponzoni, Franco Aversa, Nicola Giuliani

Research output: Contribution to journal › Article › peer-review

Abstract

The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	International Journal of Hematology
DOIs	https://doi.org/10.1007/s12185-016-2104-1
Publication status	Accepted/In press - Oct 3 2016

Keywords

Bone marrow
Extramedullary disease
Multiple myeloma
Skin homing

ASJC Scopus subject areas

Hematology

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10.1007/s12185-016-2104-1

Cite this

Marchica, V., Accardi, F., Storti, P., Mancini, C., Martella, E., Dalla Palma, B., Bolzoni, M., Todoerti, K., Marcatti, M., Schifano, C., Bonomini, S., Sammarelli, G., Neri, A., Ponzoni, M., Aversa, F., & Giuliani, N. (Accepted/In press). Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin? International Journal of Hematology, 1-5. https://doi.org/10.1007/s12185-016-2104-1

Marchica, V, Accardi, F, Storti, P, Mancini, C, Martella, E, Dalla Palma, B, Bolzoni, M, Todoerti, K, Marcatti, M, Schifano, C, Bonomini, S, Sammarelli, G, Neri, A , Ponzoni, M, Aversa, F & Giuliani, N 2016, 'Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?', International Journal of Hematology, pp. 1-5. https://doi.org/10.1007/s12185-016-2104-1

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title = "Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?",

abstract = "The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.",

keywords = "Bone marrow, Extramedullary disease, Multiple myeloma, Skin homing",

author = "Valentina Marchica and Fabrizio Accardi and Paola Storti and Cristina Mancini and Eugenia Martella and {Dalla Palma}, Benedetta and Marina Bolzoni and Katia Todoerti and Magda Marcatti and Chiara Schifano and Sabrina Bonomini and Gabriella Sammarelli and Antonino Neri and Maurilio Ponzoni and Franco Aversa and Nicola Giuliani",

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AU - Marchica, Valentina

AU - Accardi, Fabrizio

AU - Storti, Paola

AU - Mancini, Cristina

AU - Martella, Eugenia

AU - Dalla Palma, Benedetta

AU - Bolzoni, Marina

AU - Todoerti, Katia

AU - Marcatti, Magda

AU - Schifano, Chiara

AU - Bonomini, Sabrina

AU - Sammarelli, Gabriella

AU - Neri, Antonino

AU - Ponzoni, Maurilio

AU - Aversa, Franco

AU - Giuliani, Nicola

PY - 2016/10/3

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N2 - The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.

AB - The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.

KW - Bone marrow

KW - Extramedullary disease

KW - Multiple myeloma

KW - Skin homing

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Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?

Abstract

Keywords

ASJC Scopus subject areas

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