Abstract
Background
Heritability of antisocial behaviour is estimated at approximately
50% and involves multiple genes.
Aims
To investigate the cumulative genetic effects of 116 single
nucleotide polymorphisms mapping to 11 candidate serotonergic
genes and antisocial behaviours, in adolescence and in early
adulthood.
Method
Participants were 410 male members of the Quebec Longitudinal
Study of Kindergarten Children, a population-based cohort followed
up prospectively from age 6 to age 23. The serotonergic
genes were selected based on known physiological processes
and prior associations with antisocial behaviours. Antisocial
behaviours were self-reported and assessed by using semistructured
interviews in adolescence and in adulthood.
Results
Cumulative, haplotype-based contributions of serotonergic
genes conferring risk and protection for antisocial behaviours
were detected by using multilocus genetic profile risk scores
(MGPRSs) and multilocus genetic profile protection scores
(MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSs
contributed to 9.6, 8.5 and 15.2% of the variance in general
delinquency in adolescence, property/violent crimes in early
adulthood and physical partner violence in early adulthood,
respectively.
Conclusions
This study extends previous research by showing a cumulative
effect of multiple haplotypes conferring risk and protection to
antisocial behaviours in adolescence and early adulthood. The
findings further support the relevance of concomitantly considering
multiple serotonergic polymorphisms to better understand
the genetic aetiology of antisocial behaviours. Future studies
should investigate the interplay between risk and protective
haplotype-based multilocus genetic profile scores with the
environment.
Declaration of interest:
I.O.-M. holds a Canada Research Chair in the developmental
origins of vulnerability and resilience.
Keywords
Serotonin; haplotypes; genetics; multilocus genetic profile risk
scores; multilocus genetic profile protection scores.
Heritability of antisocial behaviour is estimated at approximately
50% and involves multiple genes.
Aims
To investigate the cumulative genetic effects of 116 single
nucleotide polymorphisms mapping to 11 candidate serotonergic
genes and antisocial behaviours, in adolescence and in early
adulthood.
Method
Participants were 410 male members of the Quebec Longitudinal
Study of Kindergarten Children, a population-based cohort followed
up prospectively from age 6 to age 23. The serotonergic
genes were selected based on known physiological processes
and prior associations with antisocial behaviours. Antisocial
behaviours were self-reported and assessed by using semistructured
interviews in adolescence and in adulthood.
Results
Cumulative, haplotype-based contributions of serotonergic
genes conferring risk and protection for antisocial behaviours
were detected by using multilocus genetic profile risk scores
(MGPRSs) and multilocus genetic profile protection scores
(MGPPSs). Cumulatively, haplotype-based MGPRSs and MGPPSs
contributed to 9.6, 8.5 and 15.2% of the variance in general
delinquency in adolescence, property/violent crimes in early
adulthood and physical partner violence in early adulthood,
respectively.
Conclusions
This study extends previous research by showing a cumulative
effect of multiple haplotypes conferring risk and protection to
antisocial behaviours in adolescence and early adulthood. The
findings further support the relevance of concomitantly considering
multiple serotonergic polymorphisms to better understand
the genetic aetiology of antisocial behaviours. Future studies
should investigate the interplay between risk and protective
haplotype-based multilocus genetic profile scores with the
environment.
Declaration of interest:
I.O.-M. holds a Canada Research Chair in the developmental
origins of vulnerability and resilience.
Keywords
Serotonin; haplotypes; genetics; multilocus genetic profile risk
scores; multilocus genetic profile protection scores.
| Original language | English |
|---|---|
| Number of pages | 9 |
| Journal | British Journal of Psychiatry |
| Publication status | E-pub ahead of print - 2018 |
Keywords
- Serotonin
- haplotypes
- genetics;
- multilocus genetic profile risk scores
- multilocus genetic profile protection scores