TY - JOUR
T1 - CSF metabolites in the differential diagnosis of Alzheimer's disease from frontal variant of frontotemporal dementia
AU - De Rino, Francesca
AU - Martinelli-Boneschi, Filippo
AU - Caso, Francesca
AU - Zuffi, Marta
AU - Zabeo, Matteo
AU - Passerini, Gabriella
AU - Comi, Giancarlo
AU - Magnani, Giuseppe
AU - Franceschi, Massimo
PY - 2012/10
Y1 - 2012/10
N2 - The early differentiation between Alzheimer's disease (AD) and frontal variant of frontotemporal dementia (fvFTD) is frequently difficult, albeit critical for the adequate management of patients and their caregivers. In order to assess the accuracy of CSF levels of betaamyloid 1-42 (Aβ), tau (τ) and Thr 181-phosphorilated tau (Pτ) in the early differentiation of AD from fvFTD, we designed a prospective study in which patients have been followed up for at least 2 years. Seventy-two patients with AD and 42 patients with fvFTD showed significantly different CSF levels of Pτ (increased in AD, p = 0.0001), Aβ (reduced in AD, p = 0.03), and ratios of Pτ to Aβ (p = 0.003). ROC analyses showed that the ratio P7tau;/AβAb is able to predict diagnosis with an AUC of 0.73 (optimal level being 0.16) corresponding to a sensitivity of 80% and a specificity of 68%. Our findings suggest that CSF metabolites may be the important tools in the early differential diagnosis between AD and fvFTD, albeit to be correlated with clinical, neuropsychological and bio imaging features.
AB - The early differentiation between Alzheimer's disease (AD) and frontal variant of frontotemporal dementia (fvFTD) is frequently difficult, albeit critical for the adequate management of patients and their caregivers. In order to assess the accuracy of CSF levels of betaamyloid 1-42 (Aβ), tau (τ) and Thr 181-phosphorilated tau (Pτ) in the early differentiation of AD from fvFTD, we designed a prospective study in which patients have been followed up for at least 2 years. Seventy-two patients with AD and 42 patients with fvFTD showed significantly different CSF levels of Pτ (increased in AD, p = 0.0001), Aβ (reduced in AD, p = 0.03), and ratios of Pτ to Aβ (p = 0.003). ROC analyses showed that the ratio P7tau;/AβAb is able to predict diagnosis with an AUC of 0.73 (optimal level being 0.16) corresponding to a sensitivity of 80% and a specificity of 68%. Our findings suggest that CSF metabolites may be the important tools in the early differential diagnosis between AD and fvFTD, albeit to be correlated with clinical, neuropsychological and bio imaging features.
KW - Alzheimer's disease
KW - Beta-amyloid
KW - CSF
KW - Frontotemporal dementia
KW - Phospho-tau
KW - Tau protein
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UR - http://www.scopus.com/inward/citedby.url?scp=84869235262&partnerID=8YFLogxK
U2 - 10.1007/s10072-011-0866-z
DO - 10.1007/s10072-011-0866-z
M3 - Article
C2 - 22124855
AN - SCOPUS:84869235262
SN - 1590-1874
VL - 33
SP - 973
EP - 977
JO - Neurological Sciences
JF - Neurological Sciences
IS - 5
ER -