TY - JOUR
T1 - CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies
T2 - A pilot study
AU - Zamboni, P.
AU - Menegatti, E.
AU - Weinstock-Guttman, B.
AU - Schirda, C.
AU - Cox, J. L.
AU - Malagoni, A. M.
AU - Hojnacki, D.
AU - Kennedy, C.
AU - Carl, E.
AU - Dwyer, M. G.
AU - Bergsland, N.
AU - Galeotti, R.
AU - Hussein, S.
AU - Bartolomei, I.
AU - Salvi, F.
AU - Ramanathan, M.
AU - Zivadinov, R.
PY - 2010/4
Y1 - 2010/4
N2 - Aim. We previously reported unexpectedly robust associations between vascular haemodynamic (VH) anomalies in the principal extracranial cerebral veins, causing chronic cerebrospinal venous insufficiency (CCSVI), and multiple sclerosis (MS). Aim of this study was to investigate the relationship between the VH changes and MRI measures of MS disease severity in a cross sectional survey. Methods. The number of anomalous VH criteria were measured using an echo-color Doppler, whereas CSF flow, atrophy and lesion measures were obtained from quantitative magnetic resonance imaging (MRI) analysis in sixteen consecutive relapsing-remirting MS patients, (mean age: 36.1±SD 7.3 years, disease duration: 7.5±1.9 years and median EDSS: 2.5) and in 8 healthy controls (HC) with similar age and sex distributions. Results. All 16 MS patients investigated and none of the HCs met the VH criteria for CCSVI (P
AB - Aim. We previously reported unexpectedly robust associations between vascular haemodynamic (VH) anomalies in the principal extracranial cerebral veins, causing chronic cerebrospinal venous insufficiency (CCSVI), and multiple sclerosis (MS). Aim of this study was to investigate the relationship between the VH changes and MRI measures of MS disease severity in a cross sectional survey. Methods. The number of anomalous VH criteria were measured using an echo-color Doppler, whereas CSF flow, atrophy and lesion measures were obtained from quantitative magnetic resonance imaging (MRI) analysis in sixteen consecutive relapsing-remirting MS patients, (mean age: 36.1±SD 7.3 years, disease duration: 7.5±1.9 years and median EDSS: 2.5) and in 8 healthy controls (HC) with similar age and sex distributions. Results. All 16 MS patients investigated and none of the HCs met the VH criteria for CCSVI (P
KW - Cerebrospinal fluid
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Ultrasonography, Doppler, color
KW - Venous insufficiency
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M3 - Article
C2 - 20351670
AN - SCOPUS:77952808923
SN - 0392-9590
VL - 29
SP - 140
EP - 148
JO - International Angiology
JF - International Angiology
IS - 2
ER -