Cryoglobulins and immune complexes in essential mixed cryoglobulinemia

Stefano Bombardieri, Clodoveo Ferri, Paola Migliorini, Aldo Pontrandolfo, Antonio Puccetti, Claudio Vitali, Giampiero Pasero

Research output: Contribution to journalArticlepeer-review


The authors review the role, clinico-serological correlations and the putative pathogenetic relevance of a number of immunological parameters in essential mixed cryoglobulinemia. On the whole, in spite of the fact that levels of cryoglobulins, immune complexes, complement as well as reticuloendothelial splenic function are frequently abnormal in this condition, they are generally poorly correlated with clinical features. Therefore, it is postulated that this apparent discrepancy may either be due to the contemporary presence in the same serum of many types of immune complexes with different toxicity, or to the influence of rheumatoid factor on the nature of circulating immune complexes.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalLa Ricerca in Clinica e in Laboratorio
Issue number2
Publication statusPublished - Apr 1986


  • Complement
  • Cryoglobulins
  • Essential mixed cryoglobulinemia
  • Immune complexes

ASJC Scopus subject areas

  • Clinical Biochemistry


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