Cryoglobulins and immune complexes in essential mixed cryoglobulinemia

Stefano Bombardieri; Clodoveo Ferri; Paola Migliorini; Aldo Pontrandolfo; Antonio Puccetti; Claudio Vitali; Giampiero Pasero

doi:10.1007/BF02909351

Cryoglobulins and immune complexes in essential mixed cryoglobulinemia

Stefano Bombardieri, Clodoveo Ferri, Paola Migliorini, Aldo Pontrandolfo, Antonio Puccetti, Claudio Vitali, Giampiero Pasero

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The authors review the role, clinico-serological correlations and the putative pathogenetic relevance of a number of immunological parameters in essential mixed cryoglobulinemia. On the whole, in spite of the fact that levels of cryoglobulins, immune complexes, complement as well as reticuloendothelial splenic function are frequently abnormal in this condition, they are generally poorly correlated with clinical features. Therefore, it is postulated that this apparent discrepancy may either be due to the contemporary presence in the same serum of many types of immune complexes with different toxicity, or to the influence of rheumatoid factor on the nature of circulating immune complexes.

Original language	English
Pages (from-to)	281-288
Number of pages	8
Journal	La Ricerca in Clinica e in Laboratorio
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/BF02909351
Publication status	Published - Apr 1986

Keywords

Complement
Cryoglobulins
Essential mixed cryoglobulinemia
Immune complexes

ASJC Scopus subject areas

Clinical Biochemistry

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10.1007/BF02909351

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abstract = "The authors review the role, clinico-serological correlations and the putative pathogenetic relevance of a number of immunological parameters in essential mixed cryoglobulinemia. On the whole, in spite of the fact that levels of cryoglobulins, immune complexes, complement as well as reticuloendothelial splenic function are frequently abnormal in this condition, they are generally poorly correlated with clinical features. Therefore, it is postulated that this apparent discrepancy may either be due to the contemporary presence in the same serum of many types of immune complexes with different toxicity, or to the influence of rheumatoid factor on the nature of circulating immune complexes.",

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AU - Bombardieri, Stefano

AU - Ferri, Clodoveo

AU - Migliorini, Paola

AU - Pontrandolfo, Aldo

AU - Puccetti, Antonio

AU - Vitali, Claudio

AU - Pasero, Giampiero

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AB - The authors review the role, clinico-serological correlations and the putative pathogenetic relevance of a number of immunological parameters in essential mixed cryoglobulinemia. On the whole, in spite of the fact that levels of cryoglobulins, immune complexes, complement as well as reticuloendothelial splenic function are frequently abnormal in this condition, they are generally poorly correlated with clinical features. Therefore, it is postulated that this apparent discrepancy may either be due to the contemporary presence in the same serum of many types of immune complexes with different toxicity, or to the influence of rheumatoid factor on the nature of circulating immune complexes.

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Cryoglobulins and immune complexes in essential mixed cryoglobulinemia

Abstract

Keywords

ASJC Scopus subject areas

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