Crosstalk between angiogenesis and lymphangiogenesis in tumor progression

C. Scavelli, A. Vacca, G. Di Pietro, F. Dammacco, D. Ribatti

Research output: Contribution to journalArticlepeer-review


Extensive studies have identified reliable markers of lymphatic endothelial cells, and mechanisms and molecules that regulate development and growth of the lymphatic vessels. Vascular endothelial growth factors (VEGF)-C and VEGF-D, and their cognate receptor tyrosine kinase, VEGF receptor-3 (VEGFR-3), are critical regulators of lymphangiogenesis. By binding to its endothelial cell surface receptors VEGFR-1 and VEGFR-2, VEGF-A mediates vascular leakage, endothelial proliferation and migration. Angiopoietin-2 (Ang-2) is expressed at sites of blood vessel remodeling and invasion, and factors that induce angiogenesis in vivo, such as VEGF-A, upregulate Ang-2 in endothelial cells. In this review, we summarize the literature concerning the crosstalk between angiogenesis and lymphangiogenesis in tumor progression, that is, involvement of VEGF-C, VEGF-D and VEGFR-3 in angiogenesis, and the role played by VEGF-A and Ang-2 in lymphangiogenesis, respectively.

Original languageEnglish
Pages (from-to)1054-1058
Number of pages5
Issue number6
Publication statusPublished - Jun 2004


  • Ang-2
  • Angiogenesis
  • Lymphangiogenesis
  • Tumor progression
  • VEG-A
  • VEGF-C
  • VEGF-D
  • VEGFR-3

ASJC Scopus subject areas

  • Hematology
  • Cancer Research


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