Critical role of HMGA proteins in cancer cell chemoresistance

Daniela D’Angelo; Paula Mussnich; Claudio Arra; Sabrina Battista; Alfredo Fusco

doi:10.1007/s00109-017-1520-x

Critical role of HMGA proteins in cancer cell chemoresistance

Daniela D’Angelo, Paula Mussnich, Claudio Arra, Sabrina Battista, Alfredo Fusco

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Review article › peer-review

Abstract

The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.

Original language	English
Pages (from-to)	353-360
Number of pages	8
Journal	Journal of Molecular Medicine
Volume	95
Issue number	4
DOIs	https://doi.org/10.1007/s00109-017-1520-x
Publication status	Published - Apr 1 2017

Keywords

Apoptosis
Chemoresistance
DNA repair
HMGA
miRNAs

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

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10.1007/s00109-017-1520-x

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title = "Critical role of HMGA proteins in cancer cell chemoresistance",

abstract = "The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.",

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T1 - Critical role of HMGA proteins in cancer cell chemoresistance

AU - D’Angelo, Daniela

AU - Mussnich, Paula

AU - Arra, Claudio

AU - Battista, Sabrina

AU - Fusco, Alfredo

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.

AB - The high-mobility group A (HMGA) proteins are frequently overexpressed in human malignancies and correlate with the presence of metastases and reduced patient survival. Here, we highlight the main studies evidencing a critical role of HMGA in chemoresistance, mainly by activating Akt signaling, impairing p53 activity, and regulating the expression of microRNAs that target genes involved in the susceptibility of cancer cells to antineoplastic agents. Therefore, these studies account for the association of HMGA overexpression with patient poor outcome, indicating the impairment of HMGA as a fascinating perspective for effectively improving cancer therapy.

KW - Apoptosis

KW - Chemoresistance

KW - DNA repair

KW - HMGA

KW - miRNAs

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Critical role of HMGA proteins in cancer cell chemoresistance

Abstract

Keywords

ASJC Scopus subject areas

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