COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial

Chiara Agrati; Serena Di Cosimo; Daniela Fenoglio; Giovanni Apolone; Fabio Ciceri; Gennaro Ciliberto; Fausto Baldanti; Massimo Costantini; Diana Giannarelli; Giuseppe Ippolito; Franco Locatelli; Alberto Mantovani; Aldo Morrone; Fabrizio Tagliavini; Antonio Uccelli; Pier Luigi Zinzani; Nicola Silvestris; Maria Rescigno

doi:10.3389/fimmu.2021.704110

COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial

Chiara Agrati, Serena Di Cosimo, Daniela Fenoglio, Giovanni Apolone, Fabio Ciceri, Gennaro Ciliberto, Fausto Baldanti, Massimo Costantini, Diana Giannarelli, Giuseppe Ippolito, Franco Locatelli, Alberto Mantovani, Aldo Morrone, Fabrizio Tagliavini, Antonio Uccelli, Pier Luigi Zinzani, Nicola Silvestris, Maria Rescigno

Research output: Contribution to journal › Article › peer-review

Abstract

Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.

Original language	English
Pages (from-to)	704110
Journal	Frontiers in Immunology
Volume	12
DOIs	https://doi.org/10.3389/fimmu.2021.704110
Publication status	Published - Aug 10 2021

Keywords

cancer
COVID-19
immunocompromised
myasthenia
SARS-CoV-2
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2021.704110

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Agrati, C., Di Cosimo, S., Fenoglio, D., Apolone, G., Ciceri, F., Ciliberto, G., Baldanti, F., Costantini, M., Giannarelli, D., Ippolito, G., Locatelli, F., Mantovani, A., Morrone, A., Tagliavini, F., Uccelli, A., Zinzani, P. L., Silvestris, N., & Rescigno, M. (2021). COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial. Frontiers in Immunology, 12, 704110. https://doi.org/10.3389/fimmu.2021.704110

Agrati, C , Di Cosimo, S , Fenoglio, D , Apolone, G, Ciceri, F, Ciliberto, G , Baldanti, F, Costantini, M, Giannarelli, D , Ippolito, G, Locatelli, F, Mantovani, A , Morrone, A, Tagliavini, F, Uccelli, A , Zinzani, PL , Silvestris, N & Rescigno, M 2021, 'COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial', Frontiers in Immunology, vol. 12, pp. 704110. https://doi.org/10.3389/fimmu.2021.704110

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abstract = "Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.",

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AU - Ciceri, Fabio

AU - Ciliberto, Gennaro

AU - Baldanti, Fausto

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AU - Tagliavini, Fabrizio

AU - Uccelli, Antonio

AU - Zinzani, Pier Luigi

AU - Silvestris, Nicola

AU - Rescigno, Maria

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COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial

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Keywords

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