COVID-19 and celiac disease: A pathogenetic hypothesis for a celiac outbreak

Chiara Maria Trovato, Monica Montuori, Nicoletta Pietropaoli, Salvatore Oliva

Research output: Contribution to journalArticlepeer-review


BACKGROUND: A growing body of evidence supports the intestinal trophism of SARS-CoV-2, with ciliated cells and intestinal enterocytes being target cells because of the high expression of ACE2 and TMPRSS2. Indeed, COVID-19 promotes a "cytokine storm" in the intestinal mucosa: the resulting epithelial damage leads to increased barrier permeability, allowing the passage of gliadin in the intestinal lamina.

METHODS: Based on current literature, we hypothesize the role of COVID-19 as a potential trigger factor for celiac disease in predisposed patients.

CONCLUSIONS: Genetically predisposed patients could be more likely to develop celiac disease following SARS-CoV-2 infection, making COVID-19 a candidate culprit for a potential outbreak of celiac disease in the forthcoming future.

Original languageEnglish
Pages (from-to)e14452
JournalInternational Journal of Clinical Practice
Issue number9
Publication statusPublished - Sept 2021


  • COVID-19
  • Celiac Disease/epidemiology
  • Disease Outbreaks
  • Gliadin
  • Humans
  • SARS-CoV-2


Dive into the research topics of 'COVID-19 and celiac disease: A pathogenetic hypothesis for a celiac outbreak'. Together they form a unique fingerprint.

Cite this