Analisi costi-efficacia del trattamento con n-3 PUFA nel post-infarto miocardico: I risultati dello studio GISSI-prevenzione

Translated title of the contribution: Cost-effectiveness analysis of n-3 polyunsaturated fatty acids (PUFA) after myocardial infarction

M. G. Franzosi, M. Brunetti, R. Marchioli, R. M. Marfisi, G. Tognoni, F. Valagussa

Research output: Contribution to journalArticlepeer-review


Objective: To estimate the cost-effectiveness of treatment with n-3 polyunsaturated fatty acids (PUFA) for secondary prevention after myocardial infarction (MI). Design and setting: The cost-effectiveness analysis of n-3 PUFA treatment after MI was based on morbidity and mortality data and the use of resources obtained prospectively during the 3.5 year follow-up period of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto (GISSI)-Prevenzione study. The cost-effectiveness analysis took into account the incremental number of life-years gained and the incremental costs for hospital admissions, diagnostic tests and drugs, applying a 5% discount rate. The value for money of n-3 PUFA treatment was assessed using the cost-effectiveness ratio and the number needed to treat (NNT) approach. Perspective: Third-party payer. Main outcome measures and results: The incremental cost-effectiveness ratio for n-3 PUFA in the basecase scenario was 24 603 euro (EUR, 1999 values) per life-year gained (95% confidence interval: 22 646 to 26 930). Sensitivity analysis included the analysis of extremes, producing estimates varying from EUR15 721 to EUR52 524 per life-year gained. 172 patients would need to be treated per year with n-3 PUFA, at an annual cost of EUR68 000, in order to save 1 patient. This is comparable with the NNT value, and associated annual cost for simvastatin, but less costly than that for pravastatin. Conclusions: The cost-effectiveness of long term treatment with n-3 PUFA is comparable with other drugs recently introduced in the routine care of secondary prevention after MI. Since the clinical benefit provided by n-3 PUFA is additive, this therapy should be added to the established routine practice, with additive costs.

Translated title of the contributionCost-effectiveness analysis of n-3 polyunsaturated fatty acids (PUFA) after myocardial infarction
Original languageItalian
Pages (from-to)105-114
Number of pages10
JournalPharmacoEconomics - Italian Research Articles
Issue number2
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Health Policy
  • Pharmacology


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