Cortical activity during olfactory stimulation in multiple chemical sensitivity: a 18F-FDG PET/CT study

Agostino Chiaravalloti; Marco Pagani; Alessandro Micarelli; Barbara Di Pietro; Giuseppe Genovesi; Marco Alessandrini; Orazio Schillaci

doi:10.1007/s00259-014-2969-2

Cortical activity during olfactory stimulation in multiple chemical sensitivity: a ¹⁸F-FDG PET/CT study

Agostino Chiaravalloti, Marco Pagani, Alessandro Micarelli, Barbara Di Pietro, Giuseppe Genovesi, Marco Alessandrini, Orazio Schillaci

www.neuromed.it

Research output: Contribution to journal › Article › peer-review

Abstract

Results: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.

Conclusion: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.

Purpose: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.

Methods: Two ¹⁸F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in ¹⁸F-FDG uptake were analysed by statistical parametric mapping (SPM2).

Original language	English
Pages (from-to)	733-740
Number of pages	8
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	42
Issue number	5
DOIs	https://doi.org/10.1007/s00259-014-2969-2
Publication status	Published - 2015

Keywords

Frontal cortex
Multiple chemical sensitivity
Olfactory cortex
Olfactory stimulation
PET

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Medicine(all)

Access to Document

10.1007/s00259-014-2969-2

Cite this

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title = "Cortical activity during olfactory stimulation in multiple chemical sensitivity: a 18F-FDG PET/CT study",

abstract = "Results: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.Conclusion: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.Purpose: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.Methods: Two 18F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in 18F-FDG uptake were analysed by statistical parametric mapping (SPM2).",

keywords = "Frontal cortex, Multiple chemical sensitivity, Olfactory cortex, Olfactory stimulation, PET",

author = "Agostino Chiaravalloti and Marco Pagani and Alessandro Micarelli and {Di Pietro}, Barbara and Giuseppe Genovesi and Marco Alessandrini and Orazio Schillaci",

year = "2015",

doi = "10.1007/s00259-014-2969-2",

language = "English",

volume = "42",

pages = "733--740",

journal = "European Journal of Pediatrics",

issn = "0340-6199",

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T1 - Cortical activity during olfactory stimulation in multiple chemical sensitivity

T2 - a 18F-FDG PET/CT study

AU - Chiaravalloti, Agostino

AU - Pagani, Marco

AU - Micarelli, Alessandro

AU - Di Pietro, Barbara

AU - Genovesi, Giuseppe

AU - Alessandrini, Marco

AU - Schillaci, Orazio

PY - 2015

Y1 - 2015

N2 - Results: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.Conclusion: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.Purpose: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.Methods: Two 18F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in 18F-FDG uptake were analysed by statistical parametric mapping (SPM2).

AB - Results: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.Conclusion: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.Purpose: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.Methods: Two 18F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in 18F-FDG uptake were analysed by statistical parametric mapping (SPM2).

KW - Frontal cortex

KW - Multiple chemical sensitivity

KW - Olfactory cortex

KW - Olfactory stimulation

KW - PET

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