Abstract
| Original language | English |
|---|---|
| Journal | Early Intervent. Psychiatry |
| DOIs | |
| Publication status | E-pub ahead of print - Nov 21 2019 |
Keywords
- first episode psychosis
- inflammation
- metabolism
- polygenic risk score
Fingerprint
Dive into the research topics of 'Correlations between immune and metabolic serum markers and schizophrenia/bipolar disorder polygenic risk score in first-episode psychosis: Early Intervention in Psychiatry'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Correlations between immune and metabolic serum markers and schizophrenia/bipolar disorder polygenic risk score in first-episode psychosis : Early Intervention in Psychiatry. / Maj, C.; Tosato, S.; Zanardini, R. et al.
In: Early Intervent. Psychiatry, 21.11.2019.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Correlations between immune and metabolic serum markers and schizophrenia/bipolar disorder polygenic risk score in first-episode psychosis
T2 - Early Intervention in Psychiatry
AU - Maj, C.
AU - Tosato, S.
AU - Zanardini, R.
AU - Lasalvia, A.
AU - Favaro, A.
AU - Leuci, E.
AU - De Girolamo, G.
AU - Ruggeri, M.
AU - Gennarelli, M.
AU - Bocchio-Chiavetto, L.
AU - GROUP, the GET-UP
N1 - Export Date: 10 February 2020 Correspondence Address: Bocchio-Chiavetto, L.; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliItaly; email: lbocchio@fatebenefratelli.eu Funding details: Ministry of Health, MOH, H61J08000200001, H61J08000200001, H61J08000200001, H61J08000200001 Funding text 1: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset. The full list of authors included in the GET UP Group is provided as a supplementary file. Funding information Ministry of Health, Italy: Ricerca Finalizzata 2007, Ricerca Corrente., Grant/Award Number: H61J08000200001 Funding text 2: The study was funded by the Ministry of Health, Italy: Ricerca Finalizzata 2007, Grant code H61J08000200001 and Ricerca Corrente. References: Beumer, W., Drexhage, R.C., De Wit, H., Versnel, M.A., Drexhage, H.A., Cohen, D., Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome (2012) Psychoneuroendocrinology, 37 (12), pp. 1901-1911; Beynon, A.L., Brown, M.R., Wright, R., Rees, M.I., Sheldon, I.M., Davies, J.S., Ghrelin inhibits LPS-induced release of IL-6 from mouse dopaminergic neurones (2013) Journal of Neuroinflammation, 10, p. 40; Bocchio-Chiavetto, L., Immune and metabolic alterations in first episode psychosis (FEP) patients (2018) Brain, Behavior, and Immunity, 70, pp. 315-324. , Zanardini R., Tosato S., Ventriglia M., Ferrari C., Bonetto, C., … GET UP Group; Carlini, V.P., Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice (2012) Peptides, 35 (2), pp. 160-165. , Machado D. G., Buteler F., Ghersi M., Ponzio M. F., Martini, A. C., … de Barioglio S. R; Das, S., Forer, L., Schönherr, S., Sidore, C., Locke, A.E., Kwong, A., Next-generation genotype imputation service and methods (2016) Nature Genetics, 48 (10), pp. 1284-1287. , … Fuchsberger, C; Delaneau, O., Zagury, J.-F., Marchini, J., Improved whole-chromosome phasing for disease and population genetic studies (2013) Nature Methods, 10 (1), pp. 5-6; Dzafic, I., Burianová, H., Periyasamy, S., Mowry, B., Association between schizophrenia polygenic risk and neural correlates of emotion perception (2018) Psychiatry Research Neuroimaging, 276, pp. 33-40; Frydecka, D., Krzystek-Korpacka, M., Lubeiro, A., Stramecki, F., Stańczykiewicz, B., Beszłej, J.A., Profiling inflammatory signatures of schizophrenia: A cross-sectional and meta-analysis study (2018) Brain, Behavior, and Immunity, 71, pp. 28-36. , … Misiak, J; Gnanapavan, S., Kola, B., Bustin, S.A., Morris, D.G., McGee, P., Fairclough, P., The tissue distribution of the MRNA of ghrelin and subtypes of its receptor, GHS-R, in humans (2002) The Journal of Clinical Endocrinology and Metabolism, 87 (6), p. 2988. , … Korbonits, M; Goldsmith, D.R., Rapaport, M.H., Miller, B.J., A meta-analysis of blood cytokine network alterations in psychiatric patients: Comparisons between schizophrenia, bipolar disorder and depression (2016) Molecular Psychiatry, 21 (12), pp. 1696-1709; Hansson, C., Alvarez-Crespo, M., Taube, M., Skibicka, K.P., Schmidt, L., Karlsson-Lindahl, L., Influence of ghrelin on the central serotonergic signaling system in mice (2014) Neuropharmacology, 79, pp. 498-505. , … Dickson, S. L; Harrisberger, F., Smieskova, R., Vogler, C., Egli, T., Schmidt, A., Lenz, C., Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis (2016) Translational Psychiatry, 6 (8). , … Borgwardt, S; Henriksen, M.G., Nordgaard, J., Jansson, L.B., Genetics of schizophrenia: Overview of methods, findings and limitations (2017) Frontiers in Human Neuroscience, 11, p. 322; Hong, S., Lee, E.E., Martin, A.S., Soontornniyomkij, B., Soontornniyomkij, V., Achim, C.L., Abnormalities in chemokine levels in schizophrenia and their clinical correlates (2017) Schizophrenia Research, 181, pp. 63-69. , … Jeste, D. V; Hou, L., Heilbronner, U., Degenhardt, F., Adli, M., Akiyama, K., Akula, N., Genetic variants associated with response to lithium treatment in bipolar disorder: A genome-wide association study (2016) Lancet (London, England), 387 (10023), pp. 1085-1093. , … Schulze, T. G; Ikeda, M., Saito, T., Kondo, K., Iwata, N., Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications (2018) Psychiatry and Clinical Neurosciences, 72 (2), pp. 52-63; Common polygenic variation contributes to risk of schizophrenia and bipolar disorder (2009) Nature, 460, pp. 748-752. , International Schizophrenia Consortium, Purcell, S. M., Wray, N. R., Stone, J. L., Visscher, P. M., O'Donovan, M. C., … Sklar, P; Kay, S.R., Fiszbein, A., Opler, L.A., The positive and negative syndrome scale (PANSS) for schizophrenia (1987) Schizophrenia Bulletin, 13 (2), pp. 261-276; Kluge, M., Schmidt, D., Uhr, M., Steiger, A., Ghrelin suppresses nocturnal secretion of luteinizing hormone (LH) and thyroid stimulating hormone (TSH) in patients with major depression (2013) Journal of Psychiatric Research, 47 (9), pp. 1236-1239; Kucukgoncu, S., Kosir, U., Zhou, E., Sullivan, E., Srihari, V.H., Tek, C., Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta-analysis (2019) Early Intervention in Psychiatry, 13 (5), pp. 1021-1031; Lewis, C.M., Vassos, E., Prospects for using risk scores in polygenic medicine (2017) Genome Medicine, 9 (1), p. 96; Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S.A., Anderson, J.G., Jung, S., The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress (2008) Nature Neuroscience, 11 (7), pp. 752-753. , … Zigman, J. M; Martorell, L., Muntané, G., Porta-López, S., Moreno, I., Ortega, L., Montalvo, I., Increased levels of serum leptin in the early stages of psychosis (2019) Journal of Psychiatric Research, 111, pp. 24-29. , … Vilella, E; Melah, K.E., Cerebrospinal fluid markers of Alzheimer's disease pathology and microglial activation are associated with altered white matter microstructure in asymptomatic adults at risk for Alzheimer's disease (2016) Journal of Alzheimer's Disease : JAD, 50 (3), pp. 873-886. , Lu, S. Y., Hoscheidt, S. M., Alexander, A. L., Adluru, N., Destiche, D. J., … Bendlin, B. B; Méquinion, M., Lu, S.Y.F., Hoscheidt, S.M., Alexander, A.L., Adluru, N., Destiche, D.J., Ghrelin: Central and peripheral implications in anorexia nervosa (2013) Frontiers in Endocrinology, 4, p. 15. , … Viltart, O; Minagar, A., Shapshak, P., Fujimura, R., Ownby, R., Heyes, M., Eisdorfer, C., The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis (2002) Journal of the Neurological Sciences, 202 (1-2), pp. 13-23; Mistry, S., Harrison, J.R., Smith, D.J., Escott-Price, V., Zammit, S., The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic review (2017) Schizophrenia Research, 197. , https://www.sciencedirect.com/science/article/abs/pii/S0920996417306655, 2–8. Retrieved from; Modabbernia, A., Taslimi, S., Brietzke, E., Ashrafi, M., Cytokine alterations in bipolar disorder: A meta-analysis of 30 studies (2013) Biological Psychiatry, 74 (1), pp. 15-25; Morris, A., Diabetes: Linking diabetes and schizophrenia (2017) Nature Reviews. Endocrinology, 13 (3), p. 126; Nakahara, S., Medland, S., Turner, J.A., Calhoun, V.D., Lim, K.O., Mueller, B.A., Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia (2018) Schizophrenia Research, 201. , https://www.sciencedirect.com/science/article/abs/pii/S0920996418303062?via=ihub, … van Erp T. G. M. (, 393–399. Retrieved from; Pillinger, T., Beck, K., Stubbs, B., Howes, O.D., Cholesterol and triglyceride levels in first-episode psychosis: Systematic review and meta-analysis (2017) The British Journal of Psychiatry: The Journal of Mental Science, 211 (6), pp. 339-349; Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 (2011) Nature Genetics, 43 (10), pp. 977-983; Ranlund, S., Calafato, S., Thygesen, J.H., Lin, K., Cahn, W., Crespo-Facorro, B., A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains (2018) American Journal of Medical Genetics, 177 (1), pp. 21-34. , … Bramon, E; Ruggeri, M., Bonetto, C., Lasalvia, A., Fioritti, A., de Girolamo, G., Santonastaso, P., Meneghelli, A., Feasibility and Effectiveness of a Multi-Element Psychosocial Intervention for First-Episode Psychosis: Results From the Cluster-Randomized Controlled GET UP PIANO Trial in a Catchment Area of 10 Million Inhabitants (2015) Schizophrenia Bulletin, 41 (5), pp. 1192-1203; Sato, T., Fukue, Y., Teranishi, H., Yoshida, Y., Kojima, M., Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-Deoxy-d-glucose administration (2005) Endocrinology, 146 (6), pp. 2510-2516; Biological insights from 108 schizophrenia-associated genetic loci (2014) Nature, 511 (7510), pp. 421-427; Sengupta, S.M., MacDonald, K., Fathalli, F., Yim, A., Lepage, M., Iyer, S., Joober, R., Polygenic risk score associated with specific symptom dimensions in first-episode psychosis (2017) Schizophrenia Research, 184, pp. 116-121; Shen, Y., Ou, J., Liu, M., Shi, L., Li, Y., Xiao, L., Zhao, J., Altered plasma levels of chemokines in autism and their association with social behaviors (2016) Psychiatry Research, 244, pp. 300-305; Trovão, N., Prata, J., VonDoellinger, O., Santos, S., Barbosa, M., Coelho, R., Peripheral biomarkers for first-episode psychosis-opportunities from the neuroinflammatory hypothesis of schizophrenia (2019) Psychiatry Investigation, 16 (3), pp. 177-184; Upthegrove, R., Manzanares-Teson, N., Barnes, N.M., Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis (2014) Schizophrenia Research, 155 (1-3), pp. 101-108; Vancampfort, D., Stubbs, B., Mitchell, A.J., De Hert, M., Wampers, M., Ward, P.B., Correll, C.U., Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: A systematic review and meta-analysis (2015) World Psychiatry: Official Journal of the World Psychiatric Association (WPA), 14 (3), pp. 339-347; Vassos, E., Di Forti, M., Coleman, J., Iyegbe, C., Prata, D., Euesden, J., An examination of polygenic score risk prediction in individuals with first-episode psychosis (2017) Biological Psychiatry, 81 (6), pp. 470-477; Wang, T., Zhang, X., Li, A., Zhu, M., Liu, S., Qin, W., Liu, B., Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations (2017) NeuroImage. Clinical, 14, pp. 441-449; Zanardini, R., Benussi, L., Fostinelli, S., Saraceno, C., Ciani, M., Borroni, B., Ghidoni, R., Serum C-peptide, Visfatin, Resistin, and ghrelin are altered in sporadic and GRN-associated Frontotemporal lobar degeneration (2018) Journal of Alzheimer's Disease, 61 (3), pp. 1053-1060
PY - 2019/11/21
Y1 - 2019/11/21
N2 - Aims: There is a strong interest in identifying the biological mechanisms involved in the genetic risk for psychotic disorders. In this study, we evaluated the correlation between serum concentrations of specific molecular markers and the genetic component for schizophrenia and bipolar disorder. Methods: We analysed the association between the polygenic risk score (PRS) and the serum levels of different inflammatory/metabolic markers in a sample of 81 first-episode psychosis patients (FEP) with a diagnosis of schizophrenia or bipolar disorder and 33 controls. Results: A positive correlation of schizophrenia and bipolar disorder PRS with the inflammatory marker C-C Motif Chemokine Ligand 4 serum concentration (ρ = 0.42, P = 1.56 × 10-04 and ρ = 0.40, P = 1.65 × 10-03, respectively) and a negative correlation with the serum ghrelin content (ρ = − 0.35, P = 4.27 × 10-03 and ρ = − 0.45, P = 6.05 × 10-04, respectively) were observed. Conclusion: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset. © 2019 John Wiley & Sons Australia, Ltd
AB - Aims: There is a strong interest in identifying the biological mechanisms involved in the genetic risk for psychotic disorders. In this study, we evaluated the correlation between serum concentrations of specific molecular markers and the genetic component for schizophrenia and bipolar disorder. Methods: We analysed the association between the polygenic risk score (PRS) and the serum levels of different inflammatory/metabolic markers in a sample of 81 first-episode psychosis patients (FEP) with a diagnosis of schizophrenia or bipolar disorder and 33 controls. Results: A positive correlation of schizophrenia and bipolar disorder PRS with the inflammatory marker C-C Motif Chemokine Ligand 4 serum concentration (ρ = 0.42, P = 1.56 × 10-04 and ρ = 0.40, P = 1.65 × 10-03, respectively) and a negative correlation with the serum ghrelin content (ρ = − 0.35, P = 4.27 × 10-03 and ρ = − 0.45, P = 6.05 × 10-04, respectively) were observed. Conclusion: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset. © 2019 John Wiley & Sons Australia, Ltd
KW - first episode psychosis
KW - inflammation
KW - metabolism
KW - polygenic risk score
U2 - 10.1111/eip.12906
DO - 10.1111/eip.12906
M3 - Article
SN - 1751-7885
JO - Early Intervent. Psychiatry
JF - Early Intervent. Psychiatry
ER -