|Journal||Early Intervent. Psychiatry|
|Publication status||E-pub ahead of print - Nov 21 2019|
- first episode psychosis
- polygenic risk score
FingerprintDive into the research topics of 'Correlations between immune and metabolic serum markers and schizophrenia/bipolar disorder polygenic risk score in first-episode psychosis: Early Intervention in Psychiatry'. Together they form a unique fingerprint.
Correlations between immune and metabolic serum markers and schizophrenia/bipolar disorder polygenic risk score in first-episode psychosis : Early Intervention in Psychiatry. / Maj, C.; Tosato, S.; Zanardini, R. et al.In: Early Intervent. Psychiatry, 21.11.2019.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Correlations between immune and metabolic serum markers and schizophrenia/bipolar disorder polygenic risk score in first-episode psychosis
T2 - Early Intervention in Psychiatry
AU - Maj, C.
AU - Tosato, S.
AU - Zanardini, R.
AU - Lasalvia, A.
AU - Favaro, A.
AU - Leuci, E.
AU - De Girolamo, G.
AU - Ruggeri, M.
AU - Gennarelli, M.
AU - Bocchio-Chiavetto, L.
AU - GROUP, the GET-UP
N1 - Export Date: 10 February 2020 Correspondence Address: Bocchio-Chiavetto, L.; Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliItaly; email: email@example.com Funding details: Ministry of Health, MOH, H61J08000200001, H61J08000200001, H61J08000200001, H61J08000200001 Funding text 1: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset. The full list of authors included in the GET UP Group is provided as a supplementary file. Funding information Ministry of Health, Italy: Ricerca Finalizzata 2007, Ricerca Corrente., Grant/Award Number: H61J08000200001 Funding text 2: The study was funded by the Ministry of Health, Italy: Ricerca Finalizzata 2007, Grant code H61J08000200001 and Ricerca Corrente. 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PY - 2019/11/21
Y1 - 2019/11/21
N2 - Aims: There is a strong interest in identifying the biological mechanisms involved in the genetic risk for psychotic disorders. In this study, we evaluated the correlation between serum concentrations of specific molecular markers and the genetic component for schizophrenia and bipolar disorder. Methods: We analysed the association between the polygenic risk score (PRS) and the serum levels of different inflammatory/metabolic markers in a sample of 81 first-episode psychosis patients (FEP) with a diagnosis of schizophrenia or bipolar disorder and 33 controls. Results: A positive correlation of schizophrenia and bipolar disorder PRS with the inflammatory marker C-C Motif Chemokine Ligand 4 serum concentration (ρ = 0.42, P = 1.56 × 10-04 and ρ = 0.40, P = 1.65 × 10-03, respectively) and a negative correlation with the serum ghrelin content (ρ = − 0.35, P = 4.27 × 10-03 and ρ = − 0.45, P = 6.05 × 10-04, respectively) were observed. Conclusion: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset. © 2019 John Wiley & Sons Australia, Ltd
AB - Aims: There is a strong interest in identifying the biological mechanisms involved in the genetic risk for psychotic disorders. In this study, we evaluated the correlation between serum concentrations of specific molecular markers and the genetic component for schizophrenia and bipolar disorder. Methods: We analysed the association between the polygenic risk score (PRS) and the serum levels of different inflammatory/metabolic markers in a sample of 81 first-episode psychosis patients (FEP) with a diagnosis of schizophrenia or bipolar disorder and 33 controls. Results: A positive correlation of schizophrenia and bipolar disorder PRS with the inflammatory marker C-C Motif Chemokine Ligand 4 serum concentration (ρ = 0.42, P = 1.56 × 10-04 and ρ = 0.40, P = 1.65 × 10-03, respectively) and a negative correlation with the serum ghrelin content (ρ = − 0.35, P = 4.27 × 10-03 and ρ = − 0.45, P = 6.05 × 10-04, respectively) were observed. Conclusion: These findings provide new insight into the biological underpinnings of the PRS component, thus supporting a role of the genetic liability on the inflammatory and metabolic alterations that characterize psychosis onset. © 2019 John Wiley & Sons Australia, Ltd
KW - first episode psychosis
KW - inflammation
KW - metabolism
KW - polygenic risk score
U2 - 10.1111/eip.12906
DO - 10.1111/eip.12906
M3 - Article
SN - 1751-7885
JO - Early Intervent. Psychiatry
JF - Early Intervent. Psychiatry