TY - JOUR
T1 - Coronary microvascular resistance
T2 - Methods for its quantification in humans
AU - Knaapen, Paul
AU - Camici, Paolo G.
AU - Marques, Koen M.
AU - Nijveldt, Robin
AU - Bax, Jeroen J.
AU - Westerhof, Nico
AU - Götte, Marco J W
AU - Jerosch-Herold, Michael
AU - Schelbert, Heinrich R.
AU - Lammertsma, Adriaan A.
AU - van Rossum, Albert C.
PY - 2009
Y1 - 2009
N2 - Coronary microvascular dysfunction is a topic that has recently gained considerable interest in the medical community owing to the growing awareness that microvascular dysfunction occurs in a number of myocardial disease states and has important prognostic implications. With this growing awareness, comes the desire to accurately assess the functional capacity of the coronary microcirculation for diagnostic purposes as well as to monitor the effects of therapeutic interventions that are targeted at reversing the extent of coronary microvascular dysfunction. Measurements of coronary microvascular resistance play a pivotal role in achieving that goal and several invasive and noninvasive methods have been developed for its quantification. This review is intended to provide an update pertaining to the methodology of these different imaging techniques, including the discussion of their strengths and weaknesses.
AB - Coronary microvascular dysfunction is a topic that has recently gained considerable interest in the medical community owing to the growing awareness that microvascular dysfunction occurs in a number of myocardial disease states and has important prognostic implications. With this growing awareness, comes the desire to accurately assess the functional capacity of the coronary microcirculation for diagnostic purposes as well as to monitor the effects of therapeutic interventions that are targeted at reversing the extent of coronary microvascular dysfunction. Measurements of coronary microvascular resistance play a pivotal role in achieving that goal and several invasive and noninvasive methods have been developed for its quantification. This review is intended to provide an update pertaining to the methodology of these different imaging techniques, including the discussion of their strengths and weaknesses.
KW - Coronary microvascular resistance
KW - Imaging
KW - Perfusion
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U2 - 10.1007/s00395-009-0037-z
DO - 10.1007/s00395-009-0037-z
M3 - Article
C2 - 19468781
AN - SCOPUS:70349696712
SN - 0300-8428
VL - 104
SP - 485
EP - 498
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
IS - 5
ER -