Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients

Gianpiero D’Offizi; Chiara Agrati; Ubaldo Visco-Comandini; Concetta Castilletti; Vincenzo Puro; Paola Piccolo; Marzia Montalbano; Silvia Meschi; Eleonora Tartaglia; Chiara Sorace; Sara Leone; Daniele Lapa; Germana Grassi; Delia Goletti; Giuseppe Ippolito; Francesco Vaia; Giuseppe Maria Ettorre; Raffaella Lionetti

doi:10.1111/liv.15089

Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients

Gianpiero D’Offizi, Chiara Agrati, Ubaldo Visco-Comandini, Concetta Castilletti, Vincenzo Puro, Paola Piccolo, Marzia Montalbano, Silvia Meschi, Eleonora Tartaglia, Chiara Sorace, Sara Leone, Daniele Lapa, Germana Grassi, Delia Goletti, Giuseppe Ippolito, Francesco Vaia, Giuseppe Maria Ettorre, Raffaella Lionetti

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Limited data are available on risks and benefits of anti-SARS-CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humoral and cell-mediated immune response after two doses of anti-SARS-CoV2 mRNA vaccines and compared with 51 healthy controls. Humoral response was measured by quantifying both anti-spike and neutralizing antibodies; cell-mediated response was measured by PBMC proliferation assay with IFN-γ and IL-2 production. Liver transplant recipients showed lower response rates compared with controls in both humoral and cellular arms; shorter time since transplantation and multi-drug immunosuppressive regimen containing mycophenolate mofetil were predictive of reduced response to vaccination. Specific antibody and cytokine production, though reduced, were highly correlated in transplant recipients.

Original language	English
Pages (from-to)	180-186
Number of pages	7
Journal	Liver International
Volume	42
Issue number	1
DOIs	https://doi.org/10.1111/liv.15089
Publication status	Published - Jan 2022

Keywords

anti-spike titre
liver transplant
SARS-CoV2 vaccination
T-cell immune response

ASJC Scopus subject areas

Hepatology

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10.1111/liv.15089

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D’Offizi, G., Agrati, C., Visco-Comandini, U., Castilletti, C., Puro, V., Piccolo, P., Montalbano, M., Meschi, S., Tartaglia, E., Sorace, C., Leone, S., Lapa, D., Grassi, G., Goletti, D., Ippolito, G., Vaia, F., Ettorre, G. M., & Lionetti, R. (2022). Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients. Liver International, 42(1), 180-186. https://doi.org/10.1111/liv.15089

D’Offizi, G , Agrati, C , Visco-Comandini, U, Castilletti, C, Puro, V, Piccolo, P, Montalbano, M , Meschi, S , Tartaglia, E, Sorace, C, Leone, S , Lapa, D , Grassi, G , Goletti, D , Ippolito, G , Vaia, F, Ettorre, GM & Lionetti, R 2022, 'Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients', Liver International, vol. 42, no. 1, pp. 180-186. https://doi.org/10.1111/liv.15089

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abstract = "Limited data are available on risks and benefits of anti-SARS-CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humoral and cell-mediated immune response after two doses of anti-SARS-CoV2 mRNA vaccines and compared with 51 healthy controls. Humoral response was measured by quantifying both anti-spike and neutralizing antibodies; cell-mediated response was measured by PBMC proliferation assay with IFN-γ and IL-2 production. Liver transplant recipients showed lower response rates compared with controls in both humoral and cellular arms; shorter time since transplantation and multi-drug immunosuppressive regimen containing mycophenolate mofetil were predictive of reduced response to vaccination. Specific antibody and cytokine production, though reduced, were highly correlated in transplant recipients.",

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author = "Gianpiero D{\textquoteright}Offizi and Chiara Agrati and Ubaldo Visco-Comandini and Concetta Castilletti and Vincenzo Puro and Paola Piccolo and Marzia Montalbano and Silvia Meschi and Eleonora Tartaglia and Chiara Sorace and Sara Leone and Daniele Lapa and Germana Grassi and Delia Goletti and Giuseppe Ippolito and Francesco Vaia and Ettorre, {Giuseppe Maria} and Raffaella Lionetti",

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AU - D’Offizi, Gianpiero

AU - Agrati, Chiara

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AU - Castilletti, Concetta

AU - Puro, Vincenzo

AU - Piccolo, Paola

AU - Montalbano, Marzia

AU - Meschi, Silvia

AU - Tartaglia, Eleonora

AU - Sorace, Chiara

AU - Leone, Sara

AU - Lapa, Daniele

AU - Grassi, Germana

AU - Goletti, Delia

AU - Ippolito, Giuseppe

AU - Vaia, Francesco

AU - Ettorre, Giuseppe Maria

AU - Lionetti, Raffaella

PY - 2022/1

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AB - Limited data are available on risks and benefits of anti-SARS-CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humoral and cell-mediated immune response after two doses of anti-SARS-CoV2 mRNA vaccines and compared with 51 healthy controls. Humoral response was measured by quantifying both anti-spike and neutralizing antibodies; cell-mediated response was measured by PBMC proliferation assay with IFN-γ and IL-2 production. Liver transplant recipients showed lower response rates compared with controls in both humoral and cellular arms; shorter time since transplantation and multi-drug immunosuppressive regimen containing mycophenolate mofetil were predictive of reduced response to vaccination. Specific antibody and cytokine production, though reduced, were highly correlated in transplant recipients.

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Coordinated cellular and humoral immune responses after two-dose SARS-CoV2 mRNA vaccination in liver transplant recipients

Abstract

Keywords

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