Abstract
In 24 previously untreated patients with advanced testicular carcinoma, the combination of adriamycin, vincristine and methotrexate (AVM) was tested in a prospective randomized study against a combination of non cross resistant drugs including vinblastine, bleomycin and mithramycin (VBM). Complete and partial (>50%) remission was observed in 4 out of 13 patients treated with AVM and in 3 out of 11 given VBM. In one patient receiving AVM and in two patients treated with VBM, the response at the level of previous inoperable retroperitoneal metastatic lymph nodes allowed a subsequent radical lymph node dissection. After cross over a partial response for 6 months was obtained in only one patient treated with VBM while none was observed in 4 patients receiving AVM. Both combinations were well tolerated. However, their therapeutic activity seems to be definitely lower with respect to treatment with vinblastine followed by continuous infusion with bleomycin.
| Translated title of the contribution | Controlled pilot study with combination chemotherapy in testicular carcinomas |
|---|---|
| Original language | Italian |
| Pages (from-to) | 435-444 |
| Number of pages | 10 |
| Journal | Tumori |
| Volume | 62 |
| Issue number | 4 |
| Publication status | Published - 1976 |
ASJC Scopus subject areas
- Cancer Research