Control of SIV rebound through structured treatment interruptions during early infection

F. Lori; M. G. Lewis; J. Xu; G. Varga; Jr Zinn D.E.; C. Crabbs; W. Wagner; J. Greenhouse; P. Silvera; J. Yalley-Ogunro; C. Tinelli; J. Lisziewicz

Control of SIV rebound through structured treatment interruptions during early infection

F. Lori, M. G. Lewis, J. Xu, G. Varga, Jr Zinn D.E., C. Crabbs, W. Wagner, J. Greenhouse, P. Silvera, J. Yalley-Ogunro, C. Tinelli, J. Lisziewicz

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

In a randomized controlled trial with acute simian immunodeficiency virus (SIV)-infected macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule structured treatment interruption (STI-HAART; alternating 3 weeks on and 3 weeks off therapy) suppressed viral load. In the STI-HAART group, T cell virus-specific immune response (VIR) and control of viral rebound increased concurrently during subsequent interruptions. In contrast, VIR did not increase and SlY rebounded after permanent treatment withdrawal in all animals on continuous HAART. Fixed-schedule STI-HAART appears to be an effective alternative to continuous HAART for the early treatment of retroviral infection.

Original language	English
Pages (from-to)	1591-1593
Number of pages	3
Journal	Science
Volume	290
Issue number	5496
Publication status	Published - Nov 24 2000

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Cite this

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title = "Control of SIV rebound through structured treatment interruptions during early infection",

abstract = "In a randomized controlled trial with acute simian immunodeficiency virus (SIV)-infected macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule structured treatment interruption (STI-HAART; alternating 3 weeks on and 3 weeks off therapy) suppressed viral load. In the STI-HAART group, T cell virus-specific immune response (VIR) and control of viral rebound increased concurrently during subsequent interruptions. In contrast, VIR did not increase and SlY rebounded after permanent treatment withdrawal in all animals on continuous HAART. Fixed-schedule STI-HAART appears to be an effective alternative to continuous HAART for the early treatment of retroviral infection.",

author = "F. Lori and Lewis, {M. G.} and J. Xu and G. Varga and {Zinn D.E.}, Jr and C. Crabbs and W. Wagner and J. Greenhouse and P. Silvera and J. Yalley-Ogunro and C. Tinelli and J. Lisziewicz",

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month = nov,

day = "24",

language = "English",

volume = "290",

pages = "1591--1593",

journal = "Science",

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TY - JOUR

T1 - Control of SIV rebound through structured treatment interruptions during early infection

AU - Lori, F.

AU - Lewis, M. G.

AU - Xu, J.

AU - Varga, G.

AU - Zinn D.E., Jr

AU - Crabbs, C.

AU - Wagner, W.

AU - Greenhouse, J.

AU - Silvera, P.

AU - Yalley-Ogunro, J.

AU - Tinelli, C.

AU - Lisziewicz, J.

PY - 2000/11/24

Y1 - 2000/11/24

N2 - In a randomized controlled trial with acute simian immunodeficiency virus (SIV)-infected macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule structured treatment interruption (STI-HAART; alternating 3 weeks on and 3 weeks off therapy) suppressed viral load. In the STI-HAART group, T cell virus-specific immune response (VIR) and control of viral rebound increased concurrently during subsequent interruptions. In contrast, VIR did not increase and SlY rebounded after permanent treatment withdrawal in all animals on continuous HAART. Fixed-schedule STI-HAART appears to be an effective alternative to continuous HAART for the early treatment of retroviral infection.

AB - In a randomized controlled trial with acute simian immunodeficiency virus (SIV)-infected macaques, both highly active antiretroviral therapy (HAART) and HAART with fixed-schedule structured treatment interruption (STI-HAART; alternating 3 weeks on and 3 weeks off therapy) suppressed viral load. In the STI-HAART group, T cell virus-specific immune response (VIR) and control of viral rebound increased concurrently during subsequent interruptions. In contrast, VIR did not increase and SlY rebounded after permanent treatment withdrawal in all animals on continuous HAART. Fixed-schedule STI-HAART appears to be an effective alternative to continuous HAART for the early treatment of retroviral infection.

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M3 - Article

C2 - 11090360

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JO - Science

JF - Science

IS - 5496

ER -

Control of SIV rebound through structured treatment interruptions during early infection

Abstract

ASJC Scopus subject areas

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