Congenital langerhans cell histiocytosis with placental involvement

Jefferson Terry, Francesca R. Pluchinotta, Stephen P. Sanders, Jo Anne Vergilio, Scott R. Hyde, Theonia K. Boyd

Research output: Contribution to journalArticlepeer-review


Congenital presentations of Langerhans cell histiocytosis (LCH) are exceedingly rare, and concurrent placental parenchymal involvement has not been definitively documented in the literature. We present 2 cases of congenital multisystem LCH with placental involvement resembling chronic villitis. Placental examination may provide the initial diagnostic evidence of LCH and may significantly influence patient management and outcome; however, the prognostic implications remain unclear. In a clinical context suspicious for congenital LCH, the observation of chronic villitis should prompt consideration of placental involvement by LCH.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalPediatric and Developmental Pathology
Issue number3
Publication statusPublished - May 2013


  • Congenital
  • Langerhans cell histiocytosis
  • Placenta

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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