Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases

Antonio Brucato; Chiara Grava; Maria Bortolati; Keigo Ikeda; Ornella Milanesi; Rolando Cimaz; Veronique Ramoni; Gabriele Vignati; Stefano Martinelli; Youcef Sadou; Adele Borghi; Angela Tincani; E. K L Chan; Amelia Ruffatti

doi:10.3899/jrheum.080737

Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases

Antonio Brucato, Chiara Grava, Maria Bortolati, Keigo Ikeda, Ornella Milanesi, Rolando Cimaz, Veronique Ramoni, Gabriele Vignati, Stefano Martinelli, Youcef Sadou, Adele Borghi, Angela Tincani, E. K L Chan, Amelia Ruffatti

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases. The Journal of Rheumatology

Original language	English
Pages (from-to)	1744-1748
Number of pages	5
Journal	Journal of Rheumatology
Volume	36
Issue number	8
DOIs	https://doi.org/10.3899/jrheum.080737
Publication status	Published - Aug 2009

Keywords

Antinuclear antibodies
Autoimmune diseases
Heart block

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Rheumatology

Access to Document

10.3899/jrheum.080737

Cite this

Brucato, A., Grava, C., Bortolati, M., Ikeda, K., Milanesi, O., Cimaz, R., Ramoni, V., Vignati, G., Martinelli, S., Sadou, Y., Borghi, A., Tincani, A., Chan, E. K. L., & Ruffatti, A. (2009). Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases. Journal of Rheumatology, 36(8), 1744-1748. https://doi.org/10.3899/jrheum.080737

Brucato, A, Grava, C, Bortolati, M, Ikeda, K, Milanesi, O, Cimaz, R, Ramoni, V, Vignati, G, Martinelli, S, Sadou, Y, Borghi, A, Tincani, A, Chan, EKL & Ruffatti, A 2009, 'Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases', Journal of Rheumatology, vol. 36, no. 8, pp. 1744-1748. https://doi.org/10.3899/jrheum.080737

@article{46546527939c4543aba3c2b74466d301,

title = "Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases",

abstract = "Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases. The Journal of Rheumatology",

keywords = "Antinuclear antibodies, Autoimmune diseases, Heart block",

author = "Antonio Brucato and Chiara Grava and Maria Bortolati and Keigo Ikeda and Ornella Milanesi and Rolando Cimaz and Veronique Ramoni and Gabriele Vignati and Stefano Martinelli and Youcef Sadou and Adele Borghi and Angela Tincani and Chan, {E. K L} and Amelia Ruffatti",

year = "2009",

month = aug,

doi = "10.3899/jrheum.080737",

language = "English",

volume = "36",

pages = "1744--1748",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "8",

}

TY - JOUR

T1 - Congenital heart block not associated with anti-Ro/La antibodies

T2 - Comparison with anti-Ro/La-positive cases

AU - Brucato, Antonio

AU - Grava, Chiara

AU - Bortolati, Maria

AU - Ikeda, Keigo

AU - Milanesi, Ornella

AU - Cimaz, Rolando

AU - Ramoni, Veronique

AU - Vignati, Gabriele

AU - Martinelli, Stefano

AU - Sadou, Youcef

AU - Borghi, Adele

AU - Tincani, Angela

AU - Chan, E. K L

AU - Ruffatti, Amelia

PY - 2009/8

Y1 - 2009/8

N2 - Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases. The Journal of Rheumatology

AB - Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases. The Journal of Rheumatology

KW - Antinuclear antibodies

KW - Autoimmune diseases

KW - Heart block

UR - http://www.scopus.com/inward/record.url?scp=68849097885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68849097885&partnerID=8YFLogxK

U2 - 10.3899/jrheum.080737

DO - 10.3899/jrheum.080737

M3 - Article

C2 - 19567621

AN - SCOPUS:68849097885

SN - 0315-162X

VL - 36

SP - 1744

EP - 1748

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 8

ER -

Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this