Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC: Results of the European multicenter study of the French Surgical Association

Mehdi Ouaissi; Reza Kianmanesh; Emilia Ragot; Jacques Belghiti; Barbara Wildhaber; Gennaro Nuzzo; Remi Dubois; Yann Revillon; Daniel Cherqui; Daniel Azoulay; Chritian Letoublon; François René Pruvot; Adeline Roux; Jean Yves Mabrut; Jean François Gigot; Jean De Ville De Goyet; Catherine Hubert; Jan Lerut; Jean Bernard Otte; Raymond Reding; Olivier Farges; Alain Sauvanet; Oulhaci Wassila; Felice Giulante; Francesco Ardito; Maria De Rose Agostino; Thomas Gelas; Pierre Yves Mure; Jacques Baulieux; Christian Gouillat; Christian Ducerf; Sabine Irtan; Sabine Sarnacki; Alexis Laurent; Philippe Compagnon; Chady Salloum; Roger Lebeau; Olivier Risse; Stéphanie Truant; Emmanuel Boleslawski; François Corfiotti; Patrick Rat; Alexandre Doussot; Pablo Ortega-Deballon; François Paye; Pierre Balladur; Mustapha Adham; Christian Partensky; Taore Alhassane; Karim Boudjema; Catelin Tiuca Dane; Yves Patrice Le Treut; Mathieu Rinaudo; Jean Hardwigsen; Hélène Martelli; Frédéric Gauthier; Sophie Branchereau; Simon Msika; Daniel Sommacale; Jean Pierre Palot; Ahmet Ayav; Charles Alexandre Laurain; Massimo Falconi; Denis Castaing; Oriana Ciacio; René Adam; Eric Vibert; Roberto Troisi; Aude Vanlander; Stéphane Geiss; Gilles De Taffin; Denis Collet; Antonio Sa Cunha; Laurent Duguet; Bouzid Chafik; Kamal Bentabak; Abdelaziz Graba; Nicolas Meurisse; Jacques Pirenne; Lorenzo Capussotti; Serena Langelle; Nermin Halkic; Nicolas Demartines; Alessandra Cristaudi; Gaëtan Molle; Baudouin Mansvelt; Massimo Saviano; Gelmini Roberta; Ousema Baraket; Samy Bouchoucha; Bernard Sastre

doi:10.1016/j.hpb.2016.04.005

Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC: Results of the European multicenter study of the French Surgical Association

Mehdi Ouaissi, Reza Kianmanesh, Emilia Ragot, Jacques Belghiti, Barbara Wildhaber, Gennaro Nuzzo, Remi Dubois, Yann Revillon, Daniel Cherqui, Daniel Azoulay, Chritian Letoublon, François René Pruvot, Adeline Roux, Jean Yves Mabrut, Jean François Gigot, Jean De Ville De Goyet, Catherine Hubert, Jan Lerut, Jean Bernard Otte, Raymond RedingOlivier Farges, Alain Sauvanet, Oulhaci Wassila, Felice Giulante, Francesco Ardito, Maria De Rose Agostino, Thomas Gelas, Pierre Yves Mure, Jacques Baulieux, Christian Gouillat, Christian Ducerf, Sabine Irtan, Sabine Sarnacki, Alexis Laurent, Philippe Compagnon, Chady Salloum, Roger Lebeau, Olivier Risse, Stéphanie Truant, Emmanuel Boleslawski, François Corfiotti, Patrick Rat, Alexandre Doussot, Pablo Ortega-Deballon, François Paye, Pierre Balladur, Mustapha Adham, Christian Partensky, Taore Alhassane, Karim Boudjema, Catelin Tiuca Dane, Yves Patrice Le Treut, Mathieu Rinaudo, Jean Hardwigsen, Hélène Martelli, Frédéric Gauthier, Sophie Branchereau, Simon Msika, Daniel Sommacale, Jean Pierre Palot, Ahmet Ayav, Charles Alexandre Laurain, Massimo Falconi, Denis Castaing, Oriana Ciacio, René Adam, Eric Vibert, Roberto Troisi, Aude Vanlander, Stéphane Geiss, Gilles De Taffin, Denis Collet, Antonio Sa Cunha, Laurent Duguet, Bouzid Chafik, Kamal Bentabak, Abdelaziz Graba, Nicolas Meurisse, Jacques Pirenne, Lorenzo Capussotti, Serena Langelle, Nermin Halkic, Nicolas Demartines, Alessandra Cristaudi, Gaëtan Molle, Baudouin Mansvelt, Massimo Saviano, Gelmini Roberta, Ousema Baraket, Samy Bouchoucha, Bernard Sastre

IRCCS Ospedale San Raffaele

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Abstract

Aim To compare clinical presentation, operative management and short- and long-term outcomes of congenital bile duct cysts (BDC) in adults with children. Methods Retrospective multi-institutional Association Francaise de Chirurgie study of Todani types I+IVB and IVA BDC. Results During the 37-year period to 2011, 33 centers included 314 patients (98 children; 216 adults). The adult population included more high-risk patients, with more active, more frequent prior treatment (47.7% vs 11.2%; p < 0.0001), more complicated presentation (50.5% vs 35.7%; p = 0.015), more synchronous biliary cancer (11.6% vs 0%; p = 0.0118) and more major surgery (23.6% vs 2%; p < 0.0001), but this latter feature was only true for type I+IVB BDC. Compared to children, the postoperative morbidity (48.1% vs 20.4%; p < 0.0001), the need for repeat procedures and the status at follow-up were worse in adults (27% vs 8.8%; p = 0.0009). However, severe postoperative morbidity and fair or poor status at follow-up were not statistically different for type IVA BDC, irrespective of patients' age. Synchronous cancer, prior HBP surgery and Todani type IVA BDC were independent predictive factors of poor or fair long-term outcome. Conclusion BDC is a more indolent disease in children compared to adults, except for Todani type IV-A BDC.

Original language	English
Pages (from-to)	529-539
Number of pages	11
Journal	HPB
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.hpb.2016.04.005
Publication status	Published - Jun 1 2016

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/j.hpb.2016.04.005

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Ouaissi, M., Kianmanesh, R., Ragot, E., Belghiti, J., Wildhaber, B., Nuzzo, G., Dubois, R., Revillon, Y., Cherqui, D., Azoulay, D., Letoublon, C., Pruvot, F. R., Roux, A., Mabrut, J. Y., Gigot, J. F., De Goyet, J. D. V., Hubert, C., Lerut, J., Otte, J. B., ... Sastre, B. (2016). Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC: Results of the European multicenter study of the French Surgical Association. HPB, 18(6), 529-539. https://doi.org/10.1016/j.hpb.2016.04.005

Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC : Results of the European multicenter study of the French Surgical Association. / Ouaissi, Mehdi; Kianmanesh, Reza; Ragot, Emilia et al.

In: HPB, Vol. 18, No. 6, 01.06.2016, p. 529-539.

Research output: Contribution to journal › Article › peer-review

Ouaissi, M, Kianmanesh, R, Ragot, E, Belghiti, J, Wildhaber, B, Nuzzo, G, Dubois, R, Revillon, Y, Cherqui, D, Azoulay, D, Letoublon, C, Pruvot, FR, Roux, A, Mabrut, JY, Gigot, JF, De Goyet, JDV, Hubert, C, Lerut, J, Otte, JB, Reding, R, Farges, O, Sauvanet, A, Wassila, O, Giulante, F, Ardito, F, De Rose Agostino, M, Gelas, T, Mure, PY, Baulieux, J, Gouillat, C, Ducerf, C, Irtan, S, Sarnacki, S, Laurent, A, Compagnon, P, Salloum, C, Lebeau, R, Risse, O, Truant, S, Boleslawski, E, Corfiotti, F, Rat, P, Doussot, A, Ortega-Deballon, P, Paye, F, Balladur, P, Adham, M, Partensky, C, Alhassane, T, Boudjema, K, Dane, CT, Le Treut, YP, Rinaudo, M, Hardwigsen, J, Martelli, H, Gauthier, F, Branchereau, S, Msika, S, Sommacale, D, Palot, JP, Ayav, A, Laurain, CA, Falconi, M, Castaing, D, Ciacio, O, Adam, R, Vibert, E, Troisi, R, Vanlander, A, Geiss, S, De Taffin, G, Collet, D, Sa Cunha, A, Duguet, L, Chafik, B, Bentabak, K, Graba, A, Meurisse, N, Pirenne, J, Capussotti, L, Langelle, S, Halkic, N, Demartines, N, Cristaudi, A, Molle, G, Mansvelt, B, Saviano, M, Roberta, G, Baraket, O, Bouchoucha, S & Sastre, B 2016, 'Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC: Results of the European multicenter study of the French Surgical Association', HPB, vol. 18, no. 6, pp. 529-539. https://doi.org/10.1016/j.hpb.2016.04.005

@article{4e1bff4a1ef9447999189604c60d539f,

title = "Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC: Results of the European multicenter study of the French Surgical Association",

abstract = "Aim To compare clinical presentation, operative management and short- and long-term outcomes of congenital bile duct cysts (BDC) in adults with children. Methods Retrospective multi-institutional Association Francaise de Chirurgie study of Todani types I+IVB and IVA BDC. Results During the 37-year period to 2011, 33 centers included 314 patients (98 children; 216 adults). The adult population included more high-risk patients, with more active, more frequent prior treatment (47.7% vs 11.2%; p < 0.0001), more complicated presentation (50.5% vs 35.7%; p = 0.015), more synchronous biliary cancer (11.6% vs 0%; p = 0.0118) and more major surgery (23.6% vs 2%; p < 0.0001), but this latter feature was only true for type I+IVB BDC. Compared to children, the postoperative morbidity (48.1% vs 20.4%; p < 0.0001), the need for repeat procedures and the status at follow-up were worse in adults (27% vs 8.8%; p = 0.0009). However, severe postoperative morbidity and fair or poor status at follow-up were not statistically different for type IVA BDC, irrespective of patients' age. Synchronous cancer, prior HBP surgery and Todani type IVA BDC were independent predictive factors of poor or fair long-term outcome. Conclusion BDC is a more indolent disease in children compared to adults, except for Todani type IV-A BDC.",

author = "Mehdi Ouaissi and Reza Kianmanesh and Emilia Ragot and Jacques Belghiti and Barbara Wildhaber and Gennaro Nuzzo and Remi Dubois and Yann Revillon and Daniel Cherqui and Daniel Azoulay and Chritian Letoublon and Pruvot, {Fran{\c c}ois Ren{\'e}} and Adeline Roux and Mabrut, {Jean Yves} and Gigot, {Jean Fran{\c c}ois} and {De Goyet}, {Jean De Ville} and Catherine Hubert and Jan Lerut and Otte, {Jean Bernard} and Raymond Reding and Olivier Farges and Alain Sauvanet and Oulhaci Wassila and Felice Giulante and Francesco Ardito and {De Rose Agostino}, Maria and Thomas Gelas and Mure, {Pierre Yves} and Jacques Baulieux and Christian Gouillat and Christian Ducerf and Sabine Irtan and Sabine Sarnacki and Alexis Laurent and Philippe Compagnon and Chady Salloum and Roger Lebeau and Olivier Risse and St{\'e}phanie Truant and Emmanuel Boleslawski and Fran{\c c}ois Corfiotti and Patrick Rat and Alexandre Doussot and Pablo Ortega-Deballon and Fran{\c c}ois Paye and Pierre Balladur and Mustapha Adham and Christian Partensky and Taore Alhassane and Karim Boudjema and Dane, {Catelin Tiuca} and {Le Treut}, {Yves Patrice} and Mathieu Rinaudo and Jean Hardwigsen and H{\'e}l{\`e}ne Martelli and Fr{\'e}d{\'e}ric Gauthier and Sophie Branchereau and Simon Msika and Daniel Sommacale and Palot, {Jean Pierre} and Ahmet Ayav and Laurain, {Charles Alexandre} and Massimo Falconi and Denis Castaing and Oriana Ciacio and Ren{\'e} Adam and Eric Vibert and Roberto Troisi and Aude Vanlander and St{\'e}phane Geiss and {De Taffin}, Gilles and Denis Collet and {Sa Cunha}, Antonio and Laurent Duguet and Bouzid Chafik and Kamal Bentabak and Abdelaziz Graba and Nicolas Meurisse and Jacques Pirenne and Lorenzo Capussotti and Serena Langelle and Nermin Halkic and Nicolas Demartines and Alessandra Cristaudi and Ga{\"e}tan Molle and Baudouin Mansvelt and Massimo Saviano and Gelmini Roberta and Ousema Baraket and Samy Bouchoucha and Bernard Sastre",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.hpb.2016.04.005",

language = "English",

volume = "18",

pages = "529--539",

journal = "HPB",

issn = "1365-182X",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC

T2 - Results of the European multicenter study of the French Surgical Association

AU - Ouaissi, Mehdi

AU - Kianmanesh, Reza

AU - Ragot, Emilia

AU - Belghiti, Jacques

AU - Wildhaber, Barbara

AU - Nuzzo, Gennaro

AU - Dubois, Remi

AU - Revillon, Yann

AU - Cherqui, Daniel

AU - Azoulay, Daniel

AU - Letoublon, Chritian

AU - Pruvot, François René

AU - Roux, Adeline

AU - Mabrut, Jean Yves

AU - Gigot, Jean François

AU - De Goyet, Jean De Ville

AU - Hubert, Catherine

AU - Lerut, Jan

AU - Otte, Jean Bernard

AU - Reding, Raymond

AU - Farges, Olivier

AU - Sauvanet, Alain

AU - Wassila, Oulhaci

AU - Giulante, Felice

AU - Ardito, Francesco

AU - De Rose Agostino, Maria

AU - Gelas, Thomas

AU - Mure, Pierre Yves

AU - Baulieux, Jacques

AU - Gouillat, Christian

AU - Ducerf, Christian

AU - Irtan, Sabine

AU - Sarnacki, Sabine

AU - Laurent, Alexis

AU - Compagnon, Philippe

AU - Salloum, Chady

AU - Lebeau, Roger

AU - Risse, Olivier

AU - Truant, Stéphanie

AU - Boleslawski, Emmanuel

AU - Corfiotti, François

AU - Rat, Patrick

AU - Doussot, Alexandre

AU - Ortega-Deballon, Pablo

AU - Paye, François

AU - Balladur, Pierre

AU - Adham, Mustapha

AU - Partensky, Christian

AU - Alhassane, Taore

AU - Boudjema, Karim

AU - Dane, Catelin Tiuca

AU - Le Treut, Yves Patrice

AU - Rinaudo, Mathieu

AU - Hardwigsen, Jean

AU - Martelli, Hélène

AU - Gauthier, Frédéric

AU - Branchereau, Sophie

AU - Msika, Simon

AU - Sommacale, Daniel

AU - Palot, Jean Pierre

AU - Ayav, Ahmet

AU - Laurain, Charles Alexandre

AU - Falconi, Massimo

AU - Castaing, Denis

AU - Ciacio, Oriana

AU - Adam, René

AU - Vibert, Eric

AU - Troisi, Roberto

AU - Vanlander, Aude

AU - Geiss, Stéphane

AU - De Taffin, Gilles

AU - Collet, Denis

AU - Sa Cunha, Antonio

AU - Duguet, Laurent

AU - Chafik, Bouzid

AU - Bentabak, Kamal

AU - Graba, Abdelaziz

AU - Meurisse, Nicolas

AU - Pirenne, Jacques

AU - Capussotti, Lorenzo

AU - Langelle, Serena

AU - Halkic, Nermin

AU - Demartines, Nicolas

AU - Cristaudi, Alessandra

AU - Molle, Gaëtan

AU - Mansvelt, Baudouin

AU - Saviano, Massimo

AU - Roberta, Gelmini

AU - Baraket, Ousema

AU - Bouchoucha, Samy

AU - Sastre, Bernard

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Aim To compare clinical presentation, operative management and short- and long-term outcomes of congenital bile duct cysts (BDC) in adults with children. Methods Retrospective multi-institutional Association Francaise de Chirurgie study of Todani types I+IVB and IVA BDC. Results During the 37-year period to 2011, 33 centers included 314 patients (98 children; 216 adults). The adult population included more high-risk patients, with more active, more frequent prior treatment (47.7% vs 11.2%; p < 0.0001), more complicated presentation (50.5% vs 35.7%; p = 0.015), more synchronous biliary cancer (11.6% vs 0%; p = 0.0118) and more major surgery (23.6% vs 2%; p < 0.0001), but this latter feature was only true for type I+IVB BDC. Compared to children, the postoperative morbidity (48.1% vs 20.4%; p < 0.0001), the need for repeat procedures and the status at follow-up were worse in adults (27% vs 8.8%; p = 0.0009). However, severe postoperative morbidity and fair or poor status at follow-up were not statistically different for type IVA BDC, irrespective of patients' age. Synchronous cancer, prior HBP surgery and Todani type IVA BDC were independent predictive factors of poor or fair long-term outcome. Conclusion BDC is a more indolent disease in children compared to adults, except for Todani type IV-A BDC.

AB - Aim To compare clinical presentation, operative management and short- and long-term outcomes of congenital bile duct cysts (BDC) in adults with children. Methods Retrospective multi-institutional Association Francaise de Chirurgie study of Todani types I+IVB and IVA BDC. Results During the 37-year period to 2011, 33 centers included 314 patients (98 children; 216 adults). The adult population included more high-risk patients, with more active, more frequent prior treatment (47.7% vs 11.2%; p < 0.0001), more complicated presentation (50.5% vs 35.7%; p = 0.015), more synchronous biliary cancer (11.6% vs 0%; p = 0.0118) and more major surgery (23.6% vs 2%; p < 0.0001), but this latter feature was only true for type I+IVB BDC. Compared to children, the postoperative morbidity (48.1% vs 20.4%; p < 0.0001), the need for repeat procedures and the status at follow-up were worse in adults (27% vs 8.8%; p = 0.0009). However, severe postoperative morbidity and fair or poor status at follow-up were not statistically different for type IVA BDC, irrespective of patients' age. Synchronous cancer, prior HBP surgery and Todani type IVA BDC were independent predictive factors of poor or fair long-term outcome. Conclusion BDC is a more indolent disease in children compared to adults, except for Todani type IV-A BDC.

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DO - 10.1016/j.hpb.2016.04.005

M3 - Article

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SN - 1365-182X

VL - 18

SP - 529

EP - 539

JO - HPB

JF - HPB

IS - 6

ER -

Congenital bile duct cyst (BDC) is a more indolent disease in children compared to adults, except for Todani type IV-A BDC: Results of the European multicenter study of the French Surgical Association

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