Concentration- and time-dependent effects of γ-linolenic acid supplementation to tumor cells in culture

S. Hrelia; A. Pession; R. Buda; A. Lorenzini; D. F. Horrobin; P. L. Biagi; A. Bordoni

doi:10.1054/plef.1999.0030

Concentration- and time-dependent effects of γ-linolenic acid supplementation to tumor cells in culture

S. Hrelia, A. Pession, R. Buda, A. Lorenzini, D. F. Horrobin, P. L. Biagi, A. Bordoni

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.

Original language	English
Pages (from-to)	235-241
Number of pages	7
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume	60
Issue number	4
DOIs	https://doi.org/10.1054/plef.1999.0030
Publication status	Published - Apr 1999

ASJC Scopus subject areas

Clinical Biochemistry
Endocrinology, Diabetes and Metabolism

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10.1054/plef.1999.0030

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abstract = "Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.",

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T1 - Concentration- and time-dependent effects of γ-linolenic acid supplementation to tumor cells in culture

AU - Hrelia, S.

AU - Pession, A.

AU - Buda, R.

AU - Lorenzini, A.

AU - Horrobin, D. F.

AU - Biagi, P. L.

AU - Bordoni, A.

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AB - Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinoma SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration- and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.

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Concentration- and time-dependent effects of γ-linolenic acid supplementation to tumor cells in culture

Abstract

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