Comparison of the effectiveness of several formulations of sodium valproate: Tablets, enteric-coated capsules, solutions and rectal capsules

D. Battino; M. Biraghi; C. Cusi; A. Nespolo; G. Avanzini

doi:10.1007/BF02043309

Comparison of the effectiveness of several formulations of sodium valproate: Tablets, enteric-coated capsules, solutions and rectal capsules

D. Battino, M. Biraghi, C. Cusi, A. Nespolo, G. Avanzini

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of an oral entericcoated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Entericcoated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric-coated form were later than after other forms. The bioavailability appeared to be the same for all the forms.

Original language	English
Pages (from-to)	197-200
Number of pages	4
Journal	Italian Journal of Neurological Sciences
Volume	3
Issue number	3
DOIs	https://doi.org/10.1007/BF02043309
Publication status	Published - Sept 1982

Keywords

antiepileptic drugs
plasma levels
Sodium valproate

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1007/BF02043309

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AU - Cusi, C.

AU - Nespolo, A.

AU - Avanzini, G.

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Comparison of the effectiveness of several formulations of sodium valproate: Tablets, enteric-coated capsules, solutions and rectal capsules

Abstract

Keywords

ASJC Scopus subject areas

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