Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems

Enrico Tortoli; Romano Mattei; Arnaldo Savarino; Laura Bartolini; Jörg Beer

doi:10.1016/S0732-8893(00)00176-0

Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems

Enrico Tortoli, Romano Mattei, Arnaldo Savarino, Laura Bartolini, Jörg Beer

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The recently introduced automated culture systems MB/BacT (Organon Teknika, Belgium) was compared with radiometric BACTEC 460TB (Becton Dickinson, USA) to test antimicrobial susceptibility of Mycobacterium tuberculosis to first line drugs. On 113 strains 97.5% agreement was obtained, with the difference being not significant. Concordance was practically complete for the most important drugs, isoniazid and rifampin. The two methods however significantly differed for the time needed to complete the test; in fact MB/BacT required on the average five days more than BACTEC 460TB. Despite the delay in the completion of the test, the excellent reliability along with the elimination of radioactivity and full automation make MB/BacT an attractive alternative for susceptibility testing of M. tuberculosis. (C) 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/S0732-8893(00)00176-0
Publication status	Published - Oct 2000

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Immunology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

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abstract = "The recently introduced automated culture systems MB/BacT (Organon Teknika, Belgium) was compared with radiometric BACTEC 460TB (Becton Dickinson, USA) to test antimicrobial susceptibility of Mycobacterium tuberculosis to first line drugs. On 113 strains 97.5% agreement was obtained, with the difference being not significant. Concordance was practically complete for the most important drugs, isoniazid and rifampin. The two methods however significantly differed for the time needed to complete the test; in fact MB/BacT required on the average five days more than BACTEC 460TB. Despite the delay in the completion of the test, the excellent reliability along with the elimination of radioactivity and full automation make MB/BacT an attractive alternative for susceptibility testing of M. tuberculosis. (C) 2000 Elsevier Science Inc.",

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AU - Savarino, Arnaldo

AU - Bartolini, Laura

AU - Beer, Jörg

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Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems

Abstract

ASJC Scopus subject areas

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