Comparison of Gonioscopy-assisted Transluminal Trabeculotomy Versus Trabeculectomy with Mitomycin C in Patients with Open-angle Glaucoma

Luigi Fontana, Michele De Maria, Alice Caristia, Valentina Mastrofilippo, Luca Braglia, Danilo Iannetta, Giuliano Pio Scarale

Research output: Contribution to journalArticlepeer-review


Précis:Trabeculectomy (TRAB) lowers the intraocular pressure (IOP) more than gonioscopy-assisted transluminal trabeculotomy (GATT) at 18 months, with a reduction in IOP of 30% or more and a significant reduction in the number of glaucoma medications compared with baseline.Purpose:To compare the IOP-lowering efficacy of GATT with mitomycin-C augmented TRAB in patients with uncontrolled open-angle glaucoma.Methods:Single-center, retrospective, comparative cohort study. One hundred ten consecutive patients (110 eyes) underwent GATT (n=61) or TRAB (n=49). The primary outcome measure was IOP reduction, defined as a percentage decrease ≥30% and absolute IOP≤18 mm Hg at 18 months with (qualified) or without (complete) medications. Secondary outcomes were visual field change, number of glaucoma medications, complications, and reintervention.Results:The mean±SD baseline IOP was 30.04±7.5 and 27.59±4.70 (P=0.072) with the mean number of medications of 3.08±0.73 and 2.92±0.91 (P=0.310) in TRAB and GATT, respectively. At 18 months, the mean±SD IOP was 15.26±3.47 mm Hg and 12.48±4.58 mm Hg after GATT and TRAB, respectively (P=0.002). The percentage of IOP lowering from baseline was 56.05±17.72 after TRAB and 42.04±15.56 after GATT (P<0.001). Percentages of complete and qualified success were 59% and 27% after TRAB and 46% and 31% after GATT (P=0.353). No change in visual field loss was observed in both groups. The mean reduction in medications was 2.3±1.4 and 2.1±1.5 in TRAB and GATT, respectively (P=0.493). The most frequent complication after TRAB was hypotony and after GATT hyphema. Reintervention occurred in 8.2% of cases after TRAB and in 14.8% after GATT (P=0.341).Conclusions:IOP lowering was greater after TRAB than after GATT at 18 months with a significant reduction in the number of medications after both procedures. Complications and reintervention occurred equally in both groups but differed in type.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalJournal of Glaucoma
Issue number1
Publication statusPublished - Jan 2021


  • glaucoma surgery
  • gonioscopy-assisted transluminal trabeculotomy
  • learning curve
  • trabeculectomy
  • trabeculotomy

ASJC Scopus subject areas

  • Ophthalmology


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