TY - JOUR
T1 - Comparison of 18F-FDG positron emission tomography/computed tomography and computed tomography in patients with already-treated breast cancer
T2 - Diagnostic and prognostic implications
AU - Evangelista, L.
AU - Baretta, Z.
AU - Vinante, L.
AU - Bezzon, E.
AU - De Carolis, V.
AU - Cervino, A. R.
AU - Gregianin, M.
AU - Ghiotto, C.
AU - Saladini, G.
AU - Pomerri, F.
AU - Muzzio, P. C.
PY - 2012/8
Y1 - 2012/8
N2 - Aim. The purpose of the study was to assess the comparison of 18F-FDG PET/CT and CT in patients with breast cancer (BC) already treated with primary therapy, in evaluating the diagnostic and prognostic values. Methods. We retrospectively studied 190 patients (187 women and 3 men, mean age 61±11 years) with previous BC (all stages) after surgery and other primary treatments. They underwent within three months CT and 18F-FDG PET/CT examinations for the evaluation of disease status. Disease relapse was confirmed by clinical evaluation and/or radiological findings. Survival curves of disease-free survival (DFS) and overall survival (OS) were computed using Kaplan-Meier method. Cox analysis regression was used to determine predictive factors of DFS and OS. Results. Of the overall 190 patients, 82 (43%) had evidence of clinical and/or imaging disease relapse, while 108 (57%) did not. Sensitivity, specificity, negative predictive and positive predictive values for disease relapse or progression were of 89% vs. 77%, 73% vs. 53%, 90% vs. 75% and 72% vs. 55%, respectively for PET/CT and CT. DFS curves were significantly different in patients with both negative and positive PET/CT and CT (log-rank test 33.6; P
AB - Aim. The purpose of the study was to assess the comparison of 18F-FDG PET/CT and CT in patients with breast cancer (BC) already treated with primary therapy, in evaluating the diagnostic and prognostic values. Methods. We retrospectively studied 190 patients (187 women and 3 men, mean age 61±11 years) with previous BC (all stages) after surgery and other primary treatments. They underwent within three months CT and 18F-FDG PET/CT examinations for the evaluation of disease status. Disease relapse was confirmed by clinical evaluation and/or radiological findings. Survival curves of disease-free survival (DFS) and overall survival (OS) were computed using Kaplan-Meier method. Cox analysis regression was used to determine predictive factors of DFS and OS. Results. Of the overall 190 patients, 82 (43%) had evidence of clinical and/or imaging disease relapse, while 108 (57%) did not. Sensitivity, specificity, negative predictive and positive predictive values for disease relapse or progression were of 89% vs. 77%, 73% vs. 53%, 90% vs. 75% and 72% vs. 55%, respectively for PET/CT and CT. DFS curves were significantly different in patients with both negative and positive PET/CT and CT (log-rank test 33.6; P
KW - Breast neoplasms
KW - Follow-up studies
KW - Positron-emission tomography and computed tomography
UR - http://www.scopus.com/inward/record.url?scp=84869746187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869746187&partnerID=8YFLogxK
M3 - Article
C2 - 23013667
AN - SCOPUS:84869746187
SN - 1824-4785
VL - 56
SP - 375
EP - 384
JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging
IS - 4
ER -